drugset / Trial / NCT01153659
A Study to Evaluate the Effect on 24-hour, Intragastric pH of RAB ER 50-mg Capsules Compared With Esomeprazole (Nexium) 40 mg Capsules and Rabeprazole (Aciphex) 20-mg Tablets
Non-randomizedCrossoverOpen-labelTreatment
Summary
This will be a randomized, open-label, single-center, 3-way crossover study in healthy subjects who are confirmed to be Helicobacter pylori (H. pylori)-negative. The study will consist of 3 study periods separated by a washout period of at least 7 days. Subjects will receive study drugs once daily for 5 days. Barring any safety concerns, subjects will be discharged from the study on Day 6 of Period 3 after completion of discharge procedures.
Timeline
- Start
- 2010-07
- Primary completion
- 2010-08
- Completion
- 2010-10
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Esomeprazole | Small molecule | 40 mg | Oral |
| Comparator | Rabeprazole | Small molecule | 20 mg | Oral |
| Comparator | Rabeprazole | Small molecule | 50 mg | Oral |
Indications
No indication recorded.