Topical Radial Artery Vasodilation

Phase 2/3 Completed 86 enrolled University of California, San Francisco

RandomizedParallel-groupQuadruple-blindTreatment

Summary

The aim of the study is to facilitate radial artery access for cardiac catheterization. The investigators hypothesize that topical nitroglycerin and lidocaine will reduce radial artery spasm. Patients undergoing cardiac catheterization via the radial artery will be randomized to topical nitroglycerin + lidocaine versus placebo.

Timeline

Start: 2010-07
Primary completion: 2011-08
Completion: 2012-08

Outcome

Met primary endpoint

paper final CSA decreased to 4.66 ± 0.25 mm(2) in the placebo group and increased to 5.78 ± 0.38 mm(2) in the treatment group (p=0.02) PMID 23582415 ↗

Publications

Beyer AT, Ng R, Singh A, Zimmet J, Shunk K, Yeghiazarians Y, Ports TA, Boyle AJ. Topical nitroglycerin and lidocaine to dilate the radial artery prior to transradial cardiac catheterization: a randomized, placebo-controlled, double-blind clinical trial: the PRE-DILATE Study. Int J Cardiol. 2013 Oct 3;168(3):2575-8. doi: 10.1016/j.ijcard.2013.03.048. Epub 2013 Apr 10.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Lidocaine	Other / unclassified	—	Topical
Subject	Nitroglycerin	Unknown	—	Topical

Indications

No indication recorded.