Hypnotic Medications and Memory: Effect of Drug Exposure During the Night

Phase 4 Completed 26 enrolled St. Luke's Hospital, Chesterfield, Missouri American Academy of Sleep Medicine · collab

RandomizedCrossoverDouble-blindBasic science

Summary

The purpose of this study is to determine the effect of two hypnotic medications, zolpidem extended release and zaleplon, on memory. It is expected that a hypnotic with shorter drug duration will allow greater memory consolidation than a hypnotic with longer drug duration.

Timeline

Start: 2010-10
Primary completion: 2011-05
Completion: 2011-05

Publications

Background Greenblatt DJ, Harmatz JS, von Moltke LL, Ehrenberg BL, Harrel L, Corbett K, Counihan M, Graf JA, Darwish M, Mertzanis P, Martin PT, Cevallos WH, Shader RI. Comparative kinetics and dynamics of zaleplon, zolpidem, and placebo. Clin Pharmacol Ther. 1998 Nov;64(5):553-61. doi: 10.1016/S0009-9236(98)90139-4.
Background Weinling E, McDougall S, Andre F, Bianchetti G, Dubruc C. Pharmacokinetic profile of a new modified release formulation of zolpidem designed to improve sleep maintenance. Fundam Clin Pharmacol. 2006 Aug;20(4):397-403. doi: 10.1111/j.1472-8206.2006.00415.x.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Zaleplon	Small molecule	10 mg	—
Subject	Zolpidem	Small molecule	12.5 mg	—

Indications

No indication recorded.