drugset / Trial / NCT01162902

Comparison of Vascular Remodeling Between Different Antianginal Medication Evaluated by Noninvasive ECG-gated Fundus Photographic Evaluation

NCT01162902

Phase 4 Unknown 150 enrolled Seoul National University Hospital
RandomizedParallel-groupSingle-blindTreatment

Summary

Treatments for stable angina includes drug therapy such as calcium-channel blocker, beta blocker, and ACEI/ARB. To obtain good prognosis in patients with coronary artery disease,preventing or correcting the progression of atherosclerosis and dyslipidemia is more important than relieving angina symptom. Dysfunction of microvessel is one of the most important factor in patients with coronary artery disease. Recently, we developed the new non-invasive method of evaluating the microvessel in fundus. With this methods, we will compare the effect of each drug (beta blocker, CCB, ARB).

Timeline

Start
2013-09
Primary completion
2015-01
Completion
2015-12

Drugs

EvaluationDrugModalityDoseRoute
Comparator Bisoprolol Other / unclassified 5 mg
Comparator Candesartan Unknown 32 mg
Subject Diltiazem Small molecule 180 mg