To Investigate Safety, Tolerability and Pharmacokinetics of TC-5214 in Healthy Male Japanese Subjects

Phase 1 Completed 48 enrolled AstraZeneca

RandomizedParallel-groupDouble-blindBasic science

Summary

The purpose of this study is to assess safety, tolerability and pharmacokinetics after a single and repeated oral doses of TC-5214 (S-mecamylamine) in healthy male Japanese subjects.

Timeline

Start: 2010-07
Primary completion: 2010-09
Completion: 2010-09

Publications

Xu H, Henningsson A, Alverlind S, Tummala R, Toler S, Beaver JS, Al-Huniti N. Population pharmacokinetics of TC-5214, a nicotinic channel modulator, in phase I and II clinical studies. J Clin Pharmacol. 2014 Jun;54(6):707-18. doi: 10.1002/jcph.264. Epub 2014 Jan 16.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	dexmecamylamine	Other / unclassified	—	Oral

Indications

No indication recorded.