drugset / Trial / NCT01176435
Trial of L-DOPA as a Treatment to Improve Vision in Albinism
RandomizedParallel-groupDouble-blindTreatment
Summary
This project will evaluate the effect of two doses of levodopa (L-DOPA) in a randomized, placebo-controlled, double-masked clinical trial to see if vision can be improved in individuals with albinism. The hypothesis is that providing L-DOPA to the retinas of these individuals may increase melanin pigment production. Increased melanin has previously been shown to be associated with improved vision.
Timeline
- Start
- 2010-09
- Primary completion
- 2014-12
- Completion
- 2014-12
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Levodopa | Small molecule | 0.51 mg/kg | Oral |
| Comparator | Levodopa | Small molecule | 0.76 mg/kg | Oral |