drugset / Trial / NCT01185197
Myfortic® for Minimal Change Nephrotic Syndrome (MCNS): a Randomized Study
RandomizedParallel-groupSingle-blindTreatment
Summary
Study objective: To investigate the potential therapeutic efficacy of enteric-coated mycophenolate sodium combined with low-dose corticosteroid as first-line treatment for minimal change nephrotic syndrome (MCNS).
Timeline
- Start
- 2010-09
- Primary completion
- 2017-06
- Completion
- 2017-06
Publications
- Azukaitis K, Palmer SC, Strippoli GF, Hodson EM. Interventions for minimal change disease in adults with nephrotic syndrome. Cochrane Database Syst Rev. 2022 Mar 1;3(3):CD001537. doi: 10.1002/14651858.CD001537.pub5.
- Ma MKM, Yap DYH, Li CL, Mok MMY, Chan GCW, Kwan LPY, Lai KN, Tang SCW. Low-dose corticosteroid and mycophenolate for primary treatment of minimal change disease. QJM. 2020 Jun 1;113(6):399-403. doi: 10.1093/qjmed/hcz297.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Prednisolone | Other / unclassified | 0.1 mg/kg | — |
| Comparator | Prednisolone | Other / unclassified | 1 mg/kg | — |
| Subject | mycophenolic acid | Small molecule | 540 mg | — |
| Subject | mycophenolic acid | Small molecule | 720 mg | — |