Morphine In Acute Myocardial Infarction

Phase 3 Completed 94 enrolled French Cardiology Society Institut National de la Santé Et de la Recherche Médicale, France · collab

RandomizedParallel-groupQuadruple-blindTreatment

Summary

The purpose of this study is to determine whether intracoronary injection of morphine chlorhydrate is effective to limit ischemia-reperfusion lesion during percutaneous coronary angioplasty in patients with acute myocardial infarction (AMI).

Timeline

Start: 2011-01
Primary completion: 2016-12
Completion: 2016-12

Outcome

Missed primary endpoint

paper Infarct size/left ventricular mass ratio was not significantly reduced by intracoronary morphine compared to placebo (27.2% ± 15.0% vs. 30.5% ± 10.6%, respectively, p = 0.28). PMID 30340532 ↗

Publications

Le Corvoisier P, Gallet R, Lesault PF, Audureau E, Paul M, Ternacle J, Ghostine S, Champagne S, Arrouasse R, Bitari D, Mouillet G, Dubois-Rande JL, Berdeaux A, Ghaleh B, Deux JF, Teiger E. Intra-coronary morphine versus placebo in the treatment of acute ST-segment elevation myocardial infarction: the MIAMI randomized controlled trial. BMC Cardiovasc Disord. 2018 Oct 19;18(1):193. doi: 10.1186/s12872-018-0936-8.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Morphine	Other / unclassified	1 mg	Other