drugset / Trial / NCT01187862
Pharmacokinetic Study to Investigate Low-dose Combinations of a Cocktail of Seven Drugs for Simultaneous Phenotyping of Cytochromes
RandomizedCrossoverOpen-labelDiagnostic
Summary
The purpose of this study is to assess whether a cocktail of seven approved drugs (so-called "Basel cocktail") can be used for simultaneous phenotyping of CYP1A2, CYP2B6, CYP2C9, CYP2C19, CYP2D6, CYP2E1 and CYP3A4.
Timeline
- Start
- 2010-07
- Primary completion
- 2011-02
- Completion
- —
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Background | Caffeine | Small molecule | — | — |
| Background | Chlorzoxazone | Small molecule | — | — |
| Background | Efavirenz | Other / unclassified | — | — |
| Background | Losartan | Other / unclassified | — | — |
| Background | Metoprolol | Other / unclassified | — | — |
| Background | Midazolam | Small molecule | — | — |
| Background | Omeprazole | Other / unclassified | — | — |
Indications
No indication recorded.