drugset / Trial / NCT01198249
Pharmacokinetic Drug Interactions Between Single and Concomitant Administrations of Amlodipine, Losartan, and Hydrochlorothiazide in Subjects With (Pre)Hypertension
RandomizedCrossoverOpen-label
Summary
This study is aimed to evaluate the pharmacokinetics and the drug-drug interaction among anti-hypertension drugs-amlodipine, losartan, and hydrochlorothiazide. This pilot study provides useful information to develop a new fixed dose combination drug.
Timeline
- Start
- 2010-09
- Primary completion
- 2011-02
- Completion
- 2011-03
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Amlodipine | Other / unclassified | 10 mg | — |
| Subject | Hydrochlorothiazide | Unknown | 25 mg | — |
| Subject | Losartan | Other / unclassified | 100 mg | — |