Pain Reduction After Cholecystectomy

Summary

To determine the effect of combined intracutaneous infiltration and intraperitoneal instillation of 80 mL 0,125% levobupivacaine prior to the start of laparoscopic cholecystectomy on abdominal pain up to 24 hours after surgery.

Timeline

Start

2009-07

Primary completion

2010-01

Completion

2010-01

Outcome

Missed primary endpoint

paper There was no significant reduction in postoperative abdominal pain with levobupivacaine compared with placebo during the 24-h follow-up; PMID 21412996 ↗

Publications

• Hilvering B, Draaisma WA, van der Bilt JD, Valk RM, Kofman KE, Consten EC. Randomized clinical trial of combined preincisional infiltration and intraperitoneal instillation of levobupivacaine for postoperative pain after laparoscopic cholecystectomy. Br J Surg. 2011 Jun;98(6):784-9. doi: 10.1002/bjs.7435. Epub 2011 Mar 17.

Drugs

Indications