The Effects of Denosumab on the Pharmacokinetics (PK) of Midazolam

Summary

This is a multi-center, open-label, drug-drug interaction study in postmenopausal women with osteoporosis.

Timeline

Start

2010-11

Primary completion

2011-07

Completion

2011-07

Publications

• Background Jang G, Kaufman A, Lee E, Hamilton L, Hutton S, Egbuna O, Padhi D. A clinical therapeutic protein drug-drug interaction study: coadministration of denosumab and midazolam in postmenopausal women with osteoporosis. Pharmacol Res Perspect. 2014 Apr;2(2):e00033. doi: 10.1002/prp2.33. Epub 2014 Mar 13.

Drugs

Indications