Perioperative Vs. Preoperative Chemotherapy With Surgery in the Squamous Carcinoma of Esophagus

Phase 1 Completed 350 enrolled Xi'an Jiaotong University

RandomizedParallel-groupSingle-blindTreatment

Summary

To assess whether or not a perioperative therapy with surgery can improve the outcomes among patients with potentially curable squamous carcinoma of esophagus as compared to a preoperative chemotherapy followed by surgery

Timeline

Start: 1997-01
Primary completion: 2008-12
Completion: 2010-01

Publications

Zhao Y, Dai Z, Min W, Sui X, Kang H, Zhang Y, Ren H, Wang XJ. Perioperative versus Preoperative Chemotherapy with Surgery in Patients with Resectable Squamous Cell Carcinoma of Esophagus: A Phase III Randomized Trial. J Thorac Oncol. 2015 Sep;10(9):1349-1356. doi: 10.1097/JTO.0000000000000612.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Capecitabine	Small molecule	625 mg/m2	—
Comparator	Cisplatin	Other / unclassified	60 mg/m2	Intravenous
Comparator	Paclitaxel	Small molecule	200 mg/m2	Intravenous
Comparator	fluorouracil	Small molecule	700 mg/m2	Intravenous

Perioperative Vs. Preoperative Chemotherapy With Surgery in the Squamous Carcinoma of Esophagus

Summary

Timeline

Publications

Drugs

Indications