Levetiracetam Versus Topiramate as Adjunctive Therapy to Evaluate Efficacy and Safety in Subjects With Refractory Partial Onset Seizures

Summary

To assess the long-term effects of levetiracetam on retention rate in subjects with refractory partial onset seizure that are not fully controlled with 1 to 3 concomitant antiepileptic drugs, compared to topiramate as add-on therapy during 52 weeks.

Timeline

Start

2010-11

Primary completion

2015-05

Completion

2015-05

Outcome

Missed primary endpoint

registry analysis (superiority or other test); Levetiracetam (Full Analysis Set) vs Topiramate (Full Analysis Set); p =0.7007; Odds Ratio (OR) 1.1 (95% CI 0.7 to 1.7); NCT01229735 ↗

Drugs

Indications