drugset / Trial / NCT01231880
School Based Malaria Control in Ugandan Schoolchildren
RandomizedParallel-groupQuadruple-blindPrevention
Summary
The investigators hypothesize that schoolchildren treated with IPT using DP over one year of follow-up will have a different risk of clinical malaria compared to those treated with placebo.
Timeline
- Start
- 2011-02
- Primary completion
- 2012-09
- Completion
- 2012-09
Outcome
Mixed primary results
paper The primary outcome was the incidence of malaria over 12 months. PMID 24621953 ↗
paper IPTm reduced the incidence of malaria by 96% (95% confidence interval [CI], 88%-99%, P < .0001) PMID 24621953 ↗
paper IPTst had no significant effect on the incidence of symptomatic malaria PMID 24621953 ↗
Publications
- Nankabirwa JI, Conrad MD, Legac J, Tukwasibwe S, Tumwebaze P, Wandera B, Brooker SJ, Staedke SG, Kamya MR, Nsobya SL, Dorsey G, Rosenthal PJ. Intermittent Preventive Treatment with Dihydroartemisinin-Piperaquine in Ugandan Schoolchildren Selects for Plasmodium falciparum Transporter Polymorphisms That Modify Drug Sensitivity. Antimicrob Agents Chemother. 2016 Sep 23;60(10):5649-54. doi: 10.1128/AAC.00920-16. Print 2016 Oct.
- Nankabirwa JI, Wandera B, Amuge P, Kiwanuka N, Dorsey G, Rosenthal PJ, Brooker SJ, Staedke SG, Kamya MR. Impact of intermittent preventive treatment with dihydroartemisinin-piperaquine on malaria in Ugandan schoolchildren: a randomized, placebo-controlled trial. Clin Infect Dis. 2014 May;58(10):1404-12. doi: 10.1093/cid/ciu150. Epub 2014 Mar 12.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | ARTENIMOL | Small molecule | — | — |
| Subject | piperaquine | Small molecule | — | — |