Drugs / ARTENIMOL
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ARTENIMOL

Small molecule

Developed for
malaria · Plasmodium falciparum malaria · Plasmodium vivax malaria · parasitemia · polycystic ovary syndrome · acne · anemia · discoid lupus erythematosus
+4 more · metabolic dysfunction-associated steatotic liver disease · sickle cell disease · systemic lupus erythematosus · androgenetic alopecia
Investigated by
University of Oxford · London School of Hygiene and Tropical Medicine · Liverpool School of Tropical Medicine · Centers for Disease Control and Prevention · University of California, San Francisco · Mahidol Oxford Tropical Medicine Research Unit
+119 more · Mahidol University · Institut de Recherche en Sciences de la Sante, Burkina Faso · Kenya Medical Research Institute · L'université de Thiès · PATH · Radboud University Medical Center · Shanghai Zhongshan Hospital · Gadjah Mada University · Indonesia-MoH · Infectious Diseases Research Collaboration, Uganda · Institute of Tropical Medicine, Belgium · Kamuzu University of Health Sciences · Kilimanjaro Christian Medical Centre, Tanzania · Kunming Pharmaceuticals, Inc. · Makerere University · Manhiça Health Research Centre · Medicines for Malaria Venture · Menzies School of Health Research · Ministry of Health, Zambia · National Centre for Parasitology, Entomology and Malaria Control, Cambodia · National Malaria Control Program, Niger · Shoklo Malaria Research Unit · Tulane University · University of Yaounde 1 · Wellcome Trust · AKROS Global Health · Albert Schweitzer Hospital · Apt. Dian Yudianto; Dr. dr Erni J. Nelwan, Sp.PD, Ph.D; Apt.Hesty Utami Ramadaniati, M.Clin, Pharm, Ph.D · Armed Forces Research Institute of Medical Sciences, Thailand · Association Camerounaise pour le Marketing Social (ACMS), Cameroon · BEIJING HOLLEY-COTEC PHARMACEUTICALS CO. LTD. · Barcelona Institute for Global Health · Bernhard Nocht Institute for Tropical Medicine · Bill and Melinda Gates Foundation · Biotechnology Center (BTC), University of Yaounde I, Cameroon · CPR Pharma Services Pty Ltd, Australia · CardiaBase · Centre Muraz · Centre de Recherche Médicale de Lambaréné · Centre for Global Health Research, Ghana · Cheikh Anta Diop University, Senegal · Department of Medical Research, Lower Myanmar · Department of State for Health and Social Welfare, The Gambia · Disease Control, Department of Health, Myanmar · East African Network for Monitoring Antimalarial Treatment · Eijkman Institute for Molecular Biology · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) · European Union · European and Developing Countries Clinical Trials Partnership (EDCTP) · FHI 360 · Fundação de Medicina Tropical Dr. Heitor Vieira Dourado · Gates Malaria Partnership · GlaxoSmithKline · Global Health Uganda LTD · Holley-Cotec Pharmaceuticals Co., LTD. · Impact Malaria, Cameroon · Imperial College London · Indiana University · Indonesia University · Johns Hopkins Bloomberg School of Public Health · KEMRI Centre for Global Health Research (CGHR), Kisumu, Kenya · KEMRI-Wellcome Trust Collaborative Research Program · Kenya National AIDS & STI Control Programme · Kwame Nkrumah University of Science and Technology · Lao-Oxford-Mahosot Hospital Wellcome Trust Research Unit · Malaria Capacity Development Consortium · Malaria Consortium · Malaria Research and Training Center, Bamako, Mali · Mbarara University of Science and Technology · Medecins Sans Frontieres, Netherlands · Medical University of Vienna · Medicines for Malaria Venture (co-sponsor) · Minister of Community Development, Mother and Child Health, Zambia · Ministry of Health, Brazil · all 125 on the full record

Trials 61 · started per year

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2004200520062007200820092010201120122013201420152016201720182019202020212022202320242025202620272028
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 01 trial
Phase 0 NCT07007078 Jun 2025 → May 2026 overdue acne Shanghai Zhongshan Hospital Recruiting No outcome recorded
Phase 13 trials
Phase 1 NCT02568098 Oct 2015 → Dec 2016 University of Oxford Completed No outcome recorded
Phase 1 NCT02184637 Jul 2014 → Apr 2015 Plasmodium vivax malaria GlaxoSmithKline Completed No outcome recorded
Phase 1 NCT01222962 Mar → May 2010 Plasmodium falciparum malaria sigma-tau i.f.r. S.p.A. Completed No outcome recorded
Phase 1/21 trial
Phase 1/2 NCT07679542 Mar → Jun 2026 overdue metabolic dysfunction-associated steatotic liver disease The First Affiliated Hospital with Nanjing Medical University Recruiting No outcome recorded
Phase 26 trials
Phase 2 NCT07557927 Apr 2026 → Sep 2028 expected discoid lupus erythematosus Kunming Pharmaceuticals, Inc. Not yet recruiting No outcome recorded
Phase 2 NCT06417099 May 2024 → Mar 2025 polycystic ovary syndrome Shanghai Zhongshan Hospital Completed No outcome recorded
Phase 2 NCT05252845 Jan → Jun 2023 Plasmodium falciparum malaria University of Oxford Completed No outcome recorded
Phase 2 NCT05829187 Nov → Dec 2022 Plasmodium falciparum malaria Syamsudin Abdillah,Ph.D, Pharm D Completed No outcome recorded
Phase 2 NCT03396393 Mar 2018 → Dec 2021 systemic lupus erythematosus Kunming Pharmaceuticals, Inc. Unknown No outcome recorded
Phase 2 NCT02909712 Sep 2016 → Jan 2020 malaria, parasitemia, poisoning London School of Hygiene and Tropical Medicine Completed No outcome recorded
Phase 2/34 trials
Phase 2/3 NCT04009343 Jun 2019 → Aug 2020 overdue Plasmodium falciparum malaria Johns Hopkins Bloomberg School of Public Health Active not recruiting No outcome recorded
Phase 2/3 NCT02461186 Jun 2015 → Jun 2017 Plasmodium falciparum malaria University of Oxford Withdrawn No outcome recorded
Phase 2/3 NCT00941785 Jul → Dec 2009 malaria London School of Hygiene and Tropical Medicine Completed No outcome recorded
Phase 2/3 NCT00561899 Aug 2007 → Feb 2008 malaria London School of Hygiene and Tropical Medicine Completed No outcome recorded
Phase 319 trials
Phase 3 NCT06962319 Sep 2025 → Aug 2028 expected malaria Liverpool School of Tropical Medicine Recruiting No outcome recorded
Phase 3 NCT05946642 Jul 2023 → May 2024 malaria Malaria Consortium Unknown No outcome recorded
Phase 3 NCT04844099 Apr 2021 → Jun 2023 malaria, sickle cell disease Liverpool School of Tropical Medicine Completed No outcome recorded
Phase 3 NCT04147546 Aug 2020 → Aug 2021 Plasmodium falciparum malaria Institut de Recherche en Sciences de la Sante, Burkina Faso Completed No outcome recorded
Phase 3 NCT04158713 Nov 2019 → Apr 2022 Liverpool School of Tropical Medicine Completed No outcome recorded
Phase 3 NCT03671109 Sep 2019 → Jul 2022 HIV infectious disease, malaria, pregnancy disorder Barcelona Institute for Global Health Completed No outcome recorded
Phase 3 NCT03576313 Aug 2018 → Dec 2019 malaria London School of Hygiene and Tropical Medicine Completed No outcome recorded
Phase 3 NCT03208907 Jul 2018 → Jul 2021 Plasmodium vivax malaria Fundação de Medicina Tropical Dr. Heitor Vieira Dourado Completed No outcome recorded
Phase 3 NCT01899820 Apr 2013 → Jun 2014 malaria Sabah Ahmed Omar Unknown No outcome recorded
Phase 3 NCT01640574 Feb 2012 → Jul 2015 Plasmodium vivax malaria University of Oxford Completed No outcome recorded
Phase 417 trials
Phase 4 NCT07246525 Aug 2026 → Aug 2029 expected malaria University of California, San Francisco Not yet recruiting No outcome recorded
Phase 4 NCT06347471 May 2024 → Nov 2025 Plasmodium falciparum malaria Infectious Diseases Research Collaboration, Uganda Completed No outcome recorded
Phase 4 NCT06225297 Jan → Dec 2024 malaria PATH Suspended No outcome recorded
Phase 4 NCT05788094 Jun 2023 → Feb 2026 overdue Plasmodium vivax malaria Shoklo Malaria Research Unit Recruiting No outcome recorded
Phase 4 NCT05465135 Jul 2022 → Mar 2023 polycystic ovary syndrome Shanghai Zhongshan Hospital Completed No outcome recorded
Phase 4 NCT05340153 Apr → Dec 2022 malaria University of Yaounde 1 Unknown No outcome recorded
Phase 4 NCT05294406 Feb 2022 → Dec 2023 malaria Liverpool School of Tropical Medicine Completed No outcome recorded
Phase 4 NCT04816461 Jul 2021 → Jun 2023 malaria Institut de Recherche en Sciences de la Sante, Burkina Faso Completed No outcome recorded
Phase 4 NCT02940756 Mar 2017 → Jan 2018 malaria Ministry of Public Health, Democratic Republic of the Congo Completed No outcome recorded
Phase 4 NCT02654912 Feb 2016 → Jun 2020 malaria PATH Completed No outcome recorded
Phase not applicable10 trials
NCT07281443 Sep 2024 → Dec 2026 expected Plasmodium falciparum malaria, parasitemia Research Institute for Development Active not recruiting No outcome recorded
NCT04864444 Jun 2021 → Dec 2022 Plasmodium falciparum malaria University of California, San Francisco Completed No outcome recorded
NCT02329301 Sep 2014 → Jun 2016 Plasmodium falciparum malaria PATH Completed No outcome recorded
NCT02001428 Jul 2014 → Mar 2016 Plasmodium falciparum malaria, Plasmodium vivax malaria Gadjah Mada University Completed No outcome recorded
NCT01640587 Nov 2013 → Mar 2017 Plasmodium falciparum malaria University of Oxford Terminated No outcome recorded
NCT01872702 Apr 2013 → Jul 2017 Plasmodium falciparum malaria University of Oxford Completed No outcome recorded
NCT01624337 May 2012 → Aug 2014 malaria Armed Forces Research Institute of Medical Sciences, Thailand Terminated No outcome recorded
NCT01326754 Aug 2011 → Jun 2012 Plasmodium falciparum malaria Centers for Disease Control and Prevention Completed No outcome recorded
NCT00868465 Apr 2009 → May 2010 malaria Radboud University Medical Center Completed No outcome recorded
NCT00157833 Jul 2004 → Aug 2005 Plasmodium falciparum malaria, Plasmodium vivax malaria Menzies School of Health Research Completed No outcome recorded
Also used as a comparator or background therapy in 42 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 01 trial
Phase 0 NCT07012486 Comparator Jun 2025 → May 2026 overdue androgenetic alopecia Shanghai Zhongshan Hospital Recruiting No outcome recorded
Phase 11 trial
Phase 1 NCT02614404 Background Nov 2015 → Dec 2016 Plasmodium falciparum malaria HuLow Completed No outcome recorded
Phase 1/21 trial
Phase 1/2 NCT02802813 Comparator Jun 2016 → Jun 2018 Plasmodium vivax malaria University of Oxford Completed No outcome recorded
Phase 28 trials
Phase 2 NCT06842524 Comparator Apr 2025 → Sep 2026 expected polycystic ovary syndrome Shanghai Zhongshan Hospital Recruiting No outcome recorded
Phase 2 NCT04661579 Background Nov 2020 → Jun 2022 Plasmodium falciparum malaria PATH Completed No outcome recorded
Phase 2 NCT04609098 Background Oct → Dec 2020 Plasmodium falciparum malaria London School of Hygiene and Tropical Medicine Completed No outcome recorded
Phase 2 NCT06036030 Comparator Jan → Apr 2019 Plasmodium falciparum malaria, Plasmodium vivax malaria Syamsudin Abdillah,Ph.D, Pharm D Completed No outcome recorded
Phase 2 NCT03697668 Comparator Sep 2017 → Dec 2018 Plasmodium falciparum malaria Nurex S.r.l. Unknown No outcome recorded
Phase 2/33 trials
Phase 2/3 NCT04049916 Comparator Sep 2019 → Jan 2020 Plasmodium falciparum malaria London School of Hygiene and Tropical Medicine Completed No outcome recorded
Phase 2/3 NCT02654730 Comparator Dec 2015 → Sep 2016 malaria London School of Hygiene and Tropical Medicine Terminated No outcome recorded
Phase 2/3 NCT02453308 Comparator Aug 2015 → Mar 2018 Plasmodium falciparum malaria University of Oxford Completed No outcome recorded
Phase 313 trials
Phase 3 NCT07082205 Comparator May 2025 → Sep 2026 expected anemia, malaria Liverpool School of Tropical Medicine Recruiting No outcome recorded
Phase 3 NCT06516042 Comparator Aug 2024 → Jan 2025 overdue Plasmodium falciparum malaria PATH Active not recruiting No outcome recorded
Phase 3 NCT04978272 Comparator Feb 2022 → May 2027 expected malaria Grant Dorsey, M.D, Ph.D. Active not recruiting No outcome recorded
Phase 3 NCT04660110 Comparator Jan → Jun 2021 malaria Makerere University Unknown No outcome recorded
Phase 3 NCT04189744 Comparator Dec 2019 → Oct 2022 Trichomonas vaginitis urogenital infection, bacterial vaginosis, malaria London School of Hygiene and Tropical Medicine Completed No outcome recorded
Phase 413 trials
Phase 4 NCT07403643 Background Apr → Dec 2026 expected malaria Curtin University Not yet recruiting No outcome recorded
Phase 4 NCT06068530 Comparator Feb 2025 → Feb 2028 expected Plasmodium falciparum malaria University of Oxford Recruiting No outcome recorded
Phase 4 NCT05323721 Comparator Jun → Nov 2022 malaria Malaria Consortium Unknown No outcome recorded
Phase 4 NCT05343312 Comparator Mar 2022 → Sep 2023 Plasmodium falciparum malaria Manhiça Health Research Centre Completed No outcome recorded
Phase 4 NCT04767191 Comparator Mar 2021 → Dec 2022 malaria Jhpiego Completed No outcome recorded
Phase not applicable2 trials
NCT07533136 Comparator May 2026 → Oct 2028 expected Plasmodium vivax malaria Walter Reed Army Institute of Research (WRAIR) Not yet recruiting No outcome recorded
NCT07389057 Comparator Nov 2023 → Nov 2026 expected Plasmodium falciparum malaria, parasitemia Noguchi Memorial Institute for Medical Research Recruiting No outcome recorded

Evidence & citations 19 cited values

Every value below carries the sentence it was read from. 108 sources stand behind the page.

FieldValueCited text
Known as ARTENIMOL ChEMBL registry synonym — accepted as the source's own label CHEMBL307261
Known as .beta.-dihydroartemisinin ChEMBL registry synonym — accepted as the source's own label CHEMBL307261
Known as Alaxin ChEMBL registry synonym — accepted as the source's own label CHEMBL307261
Known as Artemether related compound a ChEMBL registry synonym — accepted as the source's own label CHEMBL307261
Known as Artenimol component of eurartesim dihydroartemisinin ChEMBL registry synonym — accepted as the source's own label CHEMBL307261
Known as Artenimolum ChEMBL registry synonym — accepted as the source's own label CHEMBL307261
Known as Cotecxin ChEMBL registry synonym — accepted as the source's own label CHEMBL307261
Known as Cotexin ChEMBL registry synonym — accepted as the source's own label CHEMBL307261
Known as DHA “Our previous single-arm pilot trial showed that dihydroartemisinin (DHA) normalised menstrual cycles, ameliorated hyperandrogenaemia and reduced antral follicles in individuals...” PMID 42320967 Jun 2026
11

“SP plus amodiaquine (AQ), SP plus piperaquine (PQ) or dihydroartemisinin (DHA) plus PQ at monthly intervals on three occasions during the peak malaria transmission season.” PMID 20574538 Jun 2010

“Dihydroartemisinin + Piperaquine tetraphosphate (DHA+PQP) will be administered on Day 1 and at 24 hours (Day 2) and 48 hours (Day 3) post first dose administration” NCT02184637

“including dihydroartemisinin (DHA)-piperaquine + mefloquine, is a potential treatment option for multidrug-resistant Plasmodium falciparum malaria” PMID 31182525 Jul 2019

“Tablet containing 40 mg of Dihydroartemisinin (DHA) and 320 mg of Piperaquine phosphate (PQP). 4 Tablets a Day for body weight above 75 kg.” NCT01222962

DHAPQ tablets contain either 20/160mg or 40/320mg of dihydroartemisinin (DHA) and piperaquine phosphate (PQ) respectively.” NCT00393679

“Eurartesim is a fixed-dose combination product composed of dihydroartemisinin (DHA) and piperaquine phosphate (PQP).” NCT01992900

“one tablet of DHA-PIP contains 40 mg of dihydroartemisinin (DHA) and 320 mg piperaquine (PIP).” NCT02118090

“dihydroartemisinin (DHA) works to treat Androgenetic Alopecia (AGA) in female adults.” NCT07012486

“dihydroartemisin (DHA) or sulfadoxine-pyrimethamine (SP)” PMID 19784374 Sep 2009

“Dihydroartemisinin+ Paperaquine (DHA+PPQ, Artekin)” NCT00682578

DHA (dihydroartemisinin) Arm” NCT07007078

Known as Di-hydroqinghaosu ChEMBL registry synonym — accepted as the source's own label CHEMBL307261
Known as dihydroartemisinin “At each ANC visit: treatment with Dihydroartemisinin-piperaquine for three days, with the daily number of tablets depending on the weight of the woman; two tablets for women...” NCT01669941
100

Dihydroartemisinin/piperaquine tablets (Shanghai Fosun Pharmaceutical Co., Ltd.) for adult participants each contain 40 mg dihydroartemisinin and 320 mg piperaquine with a...” NCT06068530

Dihydroartemisinin/piperaquine tablets for adult patients each contain 40 mg dihydroartemisinin and 320 mg piperaquine with a therapeutic dose range between 2-10 mg/kg/day...” NCT05252845

“Our aim was to compare the safety and efficacy of dihydroartemisinin-piperaquine with that of artemether-lumefantrine in patients with uncomplicated malaria caused by...” PMID 17336652 Mar 2007

“Sixty patients received either dihydroartemisinin/piperaquine (4 mg/kg/day, 3 days; n = 33) or artesunate monotherapy (4 mg/kg/day, 3 days; n = 27) followed by...” PMID 32437557 Aug 2020

“Assessing the Feasibility of Combining Dihydroartemisinin Piperaquine and Primaquine for Malaria Mass Drug Administration in High Endemic Communities in the Eastern Region of Ghana” NCT07389057

“The reactive response consists of treating all individuals within a defined radius of each RDT-confirmed incident malaria case with dihydroartemisinin-piperaquine (DHAP).” NCT02654912

“Pharmacokinetic and Mosquito-Lethal Effects of Ivermectin (IVM), Primaquine (PQ), Dihydroartemisinin-Piperaquine (DHA-PQP) and Albendazole (ABZ) in Healthy Subjects” NCT02568098

“40 mg dihydroartemisinin/320 mg piperaquine tablets and Dihydropiperaquine 20mg/ Piperaquine 160 mg tablets),. Treatment is given according to age groups.” NCT00902811

“Administration of imatinib (400 mg/day) plus dihydroartemisinin (40 mg/day) plus piperaquine (320 mg/day) to uncomplicated adult male malaria patients.” NCT02614404

“Three monthly cycles of targeted chemoprevention with dihydroartemisinin-piperaquine (DHA-PQ) for all daara residents, regardless of resident age” NCT06225297

“Tablet containing 40 mg of Dihydroartemisinin (DHA) and 320 mg of Piperaquine phosphate (PQP). 4 Tablets a Day for body weight above 75 kg.” NCT01222962

“Eurartesim is a fixed-dose combination product composed of dihydroartemisinin (DHA) and piperaquine phosphate (PQP).” NCT01992900

“Du-Cotecxin (40mg dihydroartemisinin (DHA/320mg Piperaquine (PQP) PQP/DHA 1.6/12.8mg/kg once daily for 3 days” NCT00561899

“Mass Drug Administration With Dihydroartemisinin + Piperaquine for Reducing Malaria in Southern Zambia” NCT02329301

“one tablet of DHA-PIP contains 40 mg of dihydroartemisinin (DHA) and 320 mg piperaquine (PIP).” NCT02118090

dihydroartemisinin-piperaquine (DHAP) alone or combined with single dose of primaquine (PQ)” PMID 27825738 Oct 2016

dihydroartemisinin 2.1mg/kg and piperaquine phosphate 16.8 mg/kg once daily for three days” NCT00941785

dihydroartemisinin (DHA) works to treat Androgenetic Alopecia (AGA) in female adults.” NCT07012486

“a 3-day course of dihydroartemisinin with piperaquine-phosphate” PMID 29522113 Aug 2018

“half tablet (40mg dihydroartemisinin e 320 mg piperaquine)” NCT05343312

Dihydroartemisinin/Piperaquine (DHA-PQP or Eurartesim®)” NCT03208907

Dihydroartemisinin-piperaquine for 3 days” NCT02453308

“Drug: Dihydroartemisinin piperaquine” NCT01624337

NCT07007078

NCT01899820

NCT06516042

NCT02434952

NCT00852371

NCT04149106

NCT07679542

NCT00682578

NCT03576313

NCT01082705

NCT07403643

NCT04864444

NCT01640574

NCT00393679

NCT05788094

NCT07557927

NCT05294406

NCT00529620

NCT04767191

NCT01651416

NCT01392014

NCT01288820

NCT07246525

NCT05465135

NCT02324738

NCT02909712

NCT06962319

NCT01326754

NCT02793622

NCT06036030

NCT04049916

NCT01231113

NCT04816461

NCT02325180

NCT06842524

NCT03671109

NCT04009343

NCT00868465

NCT01389557

NCT03697668

NCT03178643

NCT06347471

NCT02282293

NCT01887821

NCT02184637

NCT02974348

NCT04660110

NCT05829187

NCT01054248

NCT05946642

NCT06417099

NCT07082205

NCT02831023

NCT01845701

NCT02802813

NCT07533136

NCT05323721

NCT04158713

NCT01640587

NCT04978272

NCT02461186

NCT04609098

NCT01743820

NCT01930331

NCT02654730

NCT04189744

NCT04661579

NCT02001428

NCT03396393

NCT04147546

NCT02671175

NCT01231880

NCT00948896

NCT00845533

NCT04844099

NCT01704508

NCT05340153

Known as Dihydroartemisinin, .beta.- ChEMBL registry synonym — accepted as the source's own label CHEMBL307261
Known as dihydroartemisinine “MDA: 2 rounds of MDA with dihydroartemisinine-piperaquine + single low dose primaquine (PQ) administered instead of SMC round 1 and 5.” NCT07281443
1

NCT02940756

Known as Dynamax ChEMBL registry synonym — accepted as the source's own label CHEMBL307261
Known as GNF-PF-5634 ChEMBL registry synonym — accepted as the source's own label CHEMBL307261
Known as Salaxin ChEMBL registry synonym — accepted as the source's own label CHEMBL307261
Known as Santecxin ChEMBL registry synonym — accepted as the source's own label CHEMBL307261
Modality Small molecule CHEMBL307261
Route Oral “dihydroartemisinin-piperaquine at an estimated total dosing of 6.75mg/kg of dihydroartemisinin and 55mg/kg of piperaquine for 3 days rounded to the nearest half tablet)” NCT01231113