drugset / Trial / NCT07246525
Intermittent Preventive Treatment of Malaria in School-age Children to Decrease Community Transmission
Phase 4
Not yet recruiting
4800 enrolled
University of California, San Francisco
Infectious Diseases Research Collaboration, Uganda · collabMinistry of Health, Uganda · collabNational Institute of Allergy and Infectious Diseases (NIAID) · collab
RandomizedParallel-groupOpen-labelPrevention
Summary
The CRITICal study aims to estimate the effectiveness of intermittent preventive treatment in school children (IPTsc) with dihydroartemisinin-piperaquine (DP) for reducing community level malaria burden. Given that school-aged children are the primary drivers of transmission, the study hypothesis is that IPTsc will reduce this infectious reservoir and thus the burden of malaria in persons of all ages in surrounding communities.
Timeline
- Start
- 2026-08-01
- Primary completion
- 2029-08-31
- Completion
- 2029-08-31
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | ARTENIMOL | Small molecule | 6.4 mg/kg | — |
| Subject | piperaquine | Small molecule | 51.2 mg/kg | — |