drugset / Trial / NCT01231919
MK2206 in Treating Younger Patients With Recurrent or Refractory Solid Tumors or Leukemia
NaSingle-groupOpen-labelTreatment
Summary
This phase I trial is studying the side effects, best way to give, and best dose of Akt inhibitor MK2206 (MK2206) in treating patients with recurrent or refractory solid tumors or leukemia. MK2206 may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth.
Timeline
- Start
- 2011-01
- Primary completion
- 2013-04
- Completion
- —
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | MK-2206 | Small molecule | — | Oral |
Indications
Burkitt lymphoma
CD4+/CD56+ hematodermic neoplasm
Hodgkins lymphoma
Waldenstrom macroglobulinemia
acute undifferentiated leukemia
aggressive NK-cell leukemia
anaplastic large cell lymphoma
atypical chronic myeloid leukemia, BCR-ABL1 negative
central nervous system non-hodgkin lymphoma
childhood acute lymphoblastic leukemia
childhood acute myeloid leukemia
chronic eosinophilic leukemia
chronic lymphocytic leukemia/small lymphocytic lymphoma
chronic myeloid leukemia
chronic neutrophilic leukemia
extranodal nasal NK/T cell lymphoma
grade III lymphomatoid granulomatosis
hairy cell leukemia
intraocular lymphoma
juvenile myelomonocytic leukemia
large-cell immunoblastic lymphoma
mantle cell lymphoma
mast cell leukemia
mycosis fungoides and variants
post-transplant lymphoproliferative disease
prolymphocytic leukemia
small intestine lymphoma
splenic marginal zone lymphoma