Drugs / MK-2206
last change May 2026 re-read 2 minutes ago

MK-2206

also known as Akt Inhibitor MK2206

Small molecule targets AKT1, AKT2, AKT3 via inhibition

Developed for
HER2 positive breast carcinoma · cancer · estrogen-receptor positive breast cancer · breast cancer · chronic lymphocytic leukemia/small lymphocytic lymphoma · female breast carcinoma · adult hepatocellular carcinoma · anaplastic large cell lymphoma
+105 more · breast carcinoma · diffuse large B-cell lymphoma · extranodal nasal NK/T cell lymphoma · gastroesophageal junction adenocarcinoma · grade III lymphomatoid granulomatosis · hairy cell leukemia · Hodgkins lymphoma · intraocular lymphoma · large-cell immunoblastic lymphoma · male breast carcinoma · mantle cell lymphoma · mycosis fungoides and variants · progesterone-receptor positive breast cancer · small intestine lymphoma · splenic marginal zone lymphoma · triple-negative breast carcinoma · Waldenstrom macroglobulinemia · acute erythroid leukemia · acute megakaryoblastic leukemia in adult · acute myeloblastic leukemia with maturation · acute myeloblastic leukemia without maturation · acute myeloid leukemia with 11q23 abnormalities · acute myeloid leukemia with minimal differentiation · acute myeloid leukemia with t(8;21)(q22;q22) translocation · acute myeloid leukemia, del(5q31-q32) · acute myeloid leukemia, inv(16)(p13.1;q22) · acute myeloid leukemia, t(16;16)(p13.1;q22) · acute myelomonocytic leukemia M4 · acute undifferentiated leukemia · adenosquamous lung carcinoma · adult acute monocytic leukemia · adult T-cell leukemia/lymphoma · aggressive NK-cell leukemia · angioimmunoblastic T-cell lymphoma · atypical chronic myeloid leukemia, BCR-ABL1 negative · Burkitt lymphoma · cancer of unknown primary site · CD4+/CD56+ hematodermic neoplasm · central nervous system non-hodgkin lymphoma · childhood acute lymphoblastic leukemia · childhood acute myeloid leukemia · cholangiocarcinoma · chronic eosinophilic leukemia · chronic myeloid leukemia · chronic neutrophilic leukemia · colon carcinoma · colon mucinous adenocarcinoma · colon signet ring cell adenocarcinoma · colorectal neoplasm · cutaneous melanoma · diffuse gastric adenocarcinoma · distal biliary tract carcinoma · endometrial adenosquamous carcinoma · endometrial clear cell adenocarcinoma · endometrial serous adenocarcinoma · esophageal cancer · estrogen-receptor negative breast cancer · fallopian tube carcinoma · gallbladder adenocarcinoma · gallbladder adenosquamous carcinoma · gallbladder carcinoma · gastric cancer · gastric intestinal type adenocarcinoma · hepatosplenic T-cell lymphoma · Her2-receptor negative breast cancer · invasive breast carcinoma · juvenile myelomonocytic leukemia · lung adenocarcinoma · lung cancer · lung large cell carcinoma · major salivary gland carcinoma · malignant glioma · MALT lymphoma · mast cell leukemia · melanoma · metastatic neoplasm · nasopharyngeal carcinoma · nasopharyngeal squamous cell carcinoma · neuroendocrine neoplasm · nodal marginal zone B-cell lymphoma · non-small cell lung carcinoma · ovarian carcinoma · ovarian sarcoma · pancreatic acinar cell carcinoma · pancreatic adenocarcinoma · pancreatic ductal adenocarcinoma · pancreatic neoplasm · peripheral T-cell lymphoma, not otherwise specified · post-transplant lymphoproliferative disease · primary cutaneous B-cell lymphoma · primary peritoneal carcinoma · progesterone-receptor negative breast cancer · prolymphocytic leukemia · prostate cancer · prostate carcinoma · rectal cancer · rectal signet ring cell adenocarcinoma · rectum mucinous adenocarcinoma · renal cell adenocarcinoma · renal cell carcinoma · salivary gland adenoid cystic carcinoma · T-cell large granular lymphocyte leukemia · testicular lymphoma · small cell lung carcinoma · thymic carcinoma
Investigated by
National Cancer Institute (NCI) · Merck Sharp & Dohme LLC · Memorial Sloan Kettering Cancer Center · Vanderbilt-Ingram Cancer Center · AstraZeneca · Beth Israel Deaconess Medical Center
+13 more · Brigham and Women's Hospital · Centre Leon Berard · Chinese University of Hong Kong · Dana-Farber Cancer Institute · GlaxoSmithKline · M.D. Anderson Cancer Center · Massachusetts General Hospital · National Cancer Institute, France · National Taiwan University Hospital · Novartis · QuantumLeap Healthcare Collaborative · University of California, Los Angeles · University of California, San Francisco

Trials 48 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 118 trials
Phase 1 NCT01783171 Jan 2013 → Jul 2016 pancreatic adenocarcinoma National Cancer Institute (NCI) Completed No outcome recorded
Phase 1 NCT01705340 Sep 2012 → May 2013 HER2 positive breast carcinoma, esophageal cancer, gastric cancer, gastroesophageal junction adenocarcinoma +1 National Cancer Institute (NCI) Terminated No outcome recorded
Phase 1 NCT01480154 Nov 2011 → Feb 2020 overdue cutaneous melanoma, prostate cancer, renal cell adenocarcinoma National Cancer Institute (NCI) Active not recruiting No outcome recorded
Phase 1 NCT01344031 Apr → Jul 2011 estrogen-receptor positive breast cancer, invasive breast carcinoma National Cancer Institute (NCI) Completed No outcome recorded
Phase 1 NCT01235897 Mar 2011 → Mar 2013 cancer University of California, San Francisco Completed No outcome recorded
Phase 1 NCT01295632 Feb 2011 → Dec 2013 cancer of unknown primary site Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 1 NCT01263145 Jan 2011 → Oct 2012 breast carcinoma National Cancer Institute (NCI) Completed No outcome recorded
Phase 1 NCT01231919 Jan 2011 → Apr 2013 Burkitt lymphoma, CD4+/CD56+ hematodermic neoplasm, Hodgkins lymphoma, Waldenstrom macroglobulinemia +24 National Cancer Institute (NCI) Completed No outcome recorded
Phase 1 NCT01281163 Jan 2011 → Dec 2013 HER2 positive breast carcinoma, estrogen-receptor negative breast cancer, estrogen-receptor positive breast cancer, progesterone-receptor negative breast cancer +1 National Cancer Institute (NCI) Terminated No outcome recorded
Phase 1 NCT01243762 Nov 2010 → Dec 2012 cancer Merck Sharp & Dohme LLC Terminated No outcome recorded
Phase 1/21 trial
Phase 1/2 NCT01369849 Sep 2011 → Feb 2014 chronic lymphocytic leukemia/small lymphocytic lymphoma National Cancer Institute (NCI) Completed No outcome recorded
Phase 229 trials
Phase 2 NCT01802320 Mar 2013 → Jun 2015 colon mucinous adenocarcinoma, colon signet ring cell adenocarcinoma, rectal signet ring cell adenocarcinoma, rectum mucinous adenocarcinoma National Cancer Institute (NCI) Completed No outcome recorded
Phase 2 NCT01776008 Jan 2013 → May 2015 Her2-receptor negative breast cancer, estrogen-receptor positive breast cancer, female breast carcinoma National Cancer Institute (NCI) Terminated No outcome recorded
Phase 2 NCT01859182 Jan → May 2013 cholangiocarcinoma, gallbladder adenocarcinoma, gallbladder adenosquamous carcinoma National Cancer Institute (NCI) Withdrawn No outcome recorded
Phase 2 NCT01658943 Aug 2012 → Jun 2015 pancreatic acinar cell carcinoma, pancreatic ductal adenocarcinoma National Cancer Institute (NCI) Completed No outcome recorded
Phase 2 NCT01604772 Jul 2012 → Oct 2013 major salivary gland carcinoma, salivary gland adenoid cystic carcinoma National Cancer Institute (NCI) Completed No outcome recorded
Phase 2 NCT01519427 Jan 2012 → May 2013 melanoma National Cancer Institute (NCI) Terminated No outcome recorded
Phase 2 NCT01481129 Dec 2011 → Jun 2013 diffuse large B-cell lymphoma National Cancer Institute (NCI) Completed No outcome recorded
Phase 2 NCT01466868 Nov 2011 → Sep 2013 diffuse large B-cell lymphoma Centre Leon Berard Terminated No outcome recorded
Phase 2 NCT01370070 Jul 2011 → Dec 2016 nasopharyngeal carcinoma Chinese University of Hong Kong Completed No outcome recorded
Phase 2 NCT01248247 Jun 2011 → Nov 2020 lung cancer M.D. Anderson Cancer Center Completed No outcome recorded
Also used as a comparator or background therapy in 1 trial
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 2 NCT01306045 Comparator Feb 2011 → Feb 2014 non-small cell lung carcinoma, small cell lung carcinoma, thymic carcinoma National Cancer Institute (NCI) Completed No outcome recorded

Evidence & citations 8 cited values

Every value below carries the sentence it was read from. 54 sources stand behind the page.

FieldValueCited text
Known as MK-2206 “To assess the activity of MK-2206 (Akt inhibitor MK2206) in patients with recurrent or persistent endometrial cancer classified by phosphoinositide-3-kinase catalytic alpha...” NCT01307631
55

“We conducted a phase II trial with an allosteric AKT inhibitor MK-2206 in patients with advanced breast cancer who had tumors with PIK3CA/AKT1 mutations and/or PTEN loss/mutation.” PMID 31277699 Jul 2019

MK-2206 was administered orally at 200 mg once weekly in 28-d cycles up to 12 cycles in the absence of progression or significant toxicity.” PMID 26213141 Jul 2015

“Preclinical and early clinical evaluation of the oral AKT inhibitor, MK-2206, for the treatment of acute myelogenous leukemia.” PMID 24583795 Feb 2014

“Patients with progressive, incurable ACC were enrolled and received MK-2206 150 mg weekly; escalation to 200 mg was allowed.” PMID 37947157 Nov 2023

MK-2206 is a potent, orally active, allosteric inhibitor of human AKT1, AKT2, and AKT3 with preclinical anti-tumor activity.” NCT01147211

MK-2206 is an oral drug (taken by mouth) that turns off a protein called AKT inside cancer cells.” NCT01235897

“Phase 2 study of MK-2206, an allosteric inhibitor of AKT, as second-line therapy” PMID 25827820 Mar 2015

MK-2206 is an orally selective allosteric inhibitor of AKT developed by MERCK” NCT01466868

“arm-B received AKT inhibitor MK-2206 200 mg 2x/week” PMID 41609418 Jan 2026

MK-2206 (Akt inhibitor MK-2206)” NCT01859182

MK-2206 (Akt inhibitor MK2206)” NCT01705340

“the pan-AKT inhibitor MK-2206PMID 25931518 Apr 2015

“Level 1: MK-2206 135mg weekly” NCT01240928

NCT01277757

NCT01243762

NCT01245205

NCT01466868

NCT01263145

NCT01658943

NCT01231919

NCT01248247

NCT01425879

NCT01169649

NCT01349933

NCT01306045

NCT01480154

NCT00963547

NCT01294306

NCT01240941

NCT01295632

NCT01705340

NCT01042379

NCT01249105

NCT01258998

NCT01239355

NCT01239342

NCT01333475

NCT01344031

NCT01283035

NCT01147211

NCT01186705

NCT00670488

NCT01021748

NCT01519427

NCT00848718

NCT01071018

NCT01481129

NCT01307631

NCT01281163

NCT01369849

NCT01859182

NCT01370070

NCT01604772

NCT01319539

NCT01802320

Known as Akt Inhibitor MK2206 ClinicalTrials.gov intervention name — accepted as the source's own label NCT01776008
Action Inhibit “MK-2206 is a potent, oral allosteric inhibitor of all AKT isoforms with antitumor activity in preclinical models.” PMID 22025163 Oct 2011
Modality Small molecule CHEMBL1079175
Route Oral “MK-2206 administered as an oral formulation” NCT00670488
Target AKT1 “allosteric inhibitor of human AKT1, AKT2, and AKT3” NCT01147211
Target AKT2 “allosteric inhibitor of human AKT1, AKT2, and AKT3” NCT01147211
Target AKT3 “allosteric inhibitor of human AKT1, AKT2, and AKT3NCT01147211