Addition of Raltegravir to Established Antiretroviral Suppressive Therapy

Summary

This study will examine whether intensification with raltegravir of a suppressive antiretroviral regimen in HIV infected patients with poor immune restoration has a beneficial effect on cryptic viral replication and the immune system. Specifically, the investigators will examine the effect that raltegravir intensification of ART has on episomal cDNA frequencies, immune activation, CD4+ cell counts and apoptosis, and markers of microbial translocation.

Timeline

Start

2010-11

Primary completion

2012-10

Completion

2013-05

Drugs

Indications