drugset / Trial / NCT01254617
Lenalidomide and Cetuximab in Treating Patients With Advanced Colorectal Cancer or Head and Neck Cancer
NaSingle-groupOpen-labelTreatment
Summary
This phase I trial studies the side effects and the best dose of lenalidomide when given together with cetuximab in treating patients with colorectal cancer or head and neck cancer that has spread to other places in the body and usually cannot be cured or controlled with treatment. Biological therapies, such as lenalidomide, use substances made from living organisms that may stimulate the immune system in different ways and stop tumor cells from growing. Monoclonal antibodies, such as cetuximab, may block tumor growth in different ways by targeting certain cells. Giving lenalidomide together with cetuximab may be a better treatment for colorectal cancer or head and neck cancer.
Timeline
- Start
- 2011-02-10
- Primary completion
- 2014-01-29
- Completion
- 2014-01-29
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Lenalidomide | Other / unclassified | — | Oral |
| Background | Cetuximab | Monoclonal antibody | — | Intravenous |
Indications
colon carcinoma
hypopharynx squamous cell carcinoma
larynx verrucous carcinoma
major salivary gland carcinoma
metastatic squamous cell carcinoma
nasal cavity and paranasal sinus squamous cell carcinoma
nasopharyngeal squamous cell carcinoma
oropharynx squamous cell carcinoma
rectal carcinoma
salivary gland squamous cell carcinoma
tongue carcinoma
verrucous carcinoma of oral cavity