drugset / Trial / NCT01263041
Effect of L-arginine and Glutamine on Preterm
RandomizedParallel-groupSingle-blindPrevention
Summary
effects of enteral l-arginine to decrease feeding intolerance and risk of NEC in neonates via its role as a NO precursor. Also, enteral glutamine which may play a role as an immunomodulator on preterm neonates. all these had never been studied in developing countries where sepsis and nec act as a major participant in mortality rates.
Timeline
- Start
- 2011-05
- Primary completion
- 2014-02
- Completion
- 2014-03
Publications
- Results Shah P, Shah V. Arginine supplementation for prevention of necrotising enterocolitis in preterm infants. Cochrane Database Syst Rev. 2007 Jul 18;(3):CD004339. doi: 10.1002/14651858.CD004339.pub3.
- El-Shimi MS, Awad HA, Abdelwahed MA, Mohamed MH, Khafagy SM, Saleh G. Enteral L-Arginine and Glutamine Supplementation for Prevention of NEC in Preterm Neonates. Int J Pediatr. 2015;2015:856091. doi: 10.1155/2015/856091. Epub 2015 Mar 12.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Glutamine | Other / unclassified | 312 mg/kg | Other |
| Subject | L-arginine | Small molecule | 260 mg/kg | Other |