Blood Sparing Strategies: Single Shot High Dose Erythropoietin Two Days Before Heart Surgery

Completed 600 enrolled Cardiochirurgia E.H.

RandomizedParallel-groupDouble-blindTreatment

Summary

All patients operated on at the European Hospital Heart surgery Division will be randomized to either single dose 80.000 UI of Human Recombinant Erythropoietin and intravenous iron or control. Primary end point is the amount of transfused blood. Secondary end point is the Hemoglobin level in the patient on postoperative day four. Ancillary analysis regarding safety at 45 days and cost effectiveness are planned as well

Timeline

Start: 2012-02
Primary completion: 2012-11
Completion: 2013-01

Publications

Nishiwaki H, Abe Y, Suzuki T, Hasegawa T, Levack WM, Noma H, Ota E. Erythropoiesis-stimulating agents for preventing acute kidney injury. Cochrane Database Syst Rev. 2024 Sep 20;9(9):CD014820. doi: 10.1002/14651858.CD014820.pub2.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	epoetin alfa	Protein / enzyme biologic	80000 iu	—
Background	Iron Sulfate	Small molecule	—	Intravenous

Indications

No indication recorded.