NeoSAMBA: Neoadjuvant: Does the Sequence of Anthracycline and Taxane Matters: Before or After?

Phase 2 Unknown 112 enrolled Brazilian National Cancer Institute Sanofi · collab

RandomizedParallel-groupOpen-labelTreatment

Summary

The purpose of this study is to evaluate the usual and the reverse sequence of an anthracycline followed by a taxane in locally advanced breast cancer.

Timeline

Start: 2010-08
Primary completion: 2020-04
Completion: 2020-06

Publications

Bines J, Small IA, Sarmento R, Kestelman F, Silva S, Rodrigues FR, Faroni L, Goncalves A, Ebecken E, Maroun P, Millen E, Bonamino M. Does the Sequence of Anthracycline and Taxane Matter? The NeoSAMBA Trial. Oncologist. 2020 Sep;25(9):758-764. doi: 10.1634/theoncologist.2019-0805. Epub 2020 Jun 23.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Cyclophosphamide	Other / unclassified	500 mg/m2	Intravenous
Comparator	Docetaxel	Small molecule	100 mg/m2	Intravenous
Comparator	Doxorubicin	Other / unclassified	50 mg/m2	Intravenous
Comparator	fluorouracil	Small molecule	500 mg/m2	Intravenous

NeoSAMBA: Neoadjuvant: Does the Sequence of Anthracycline and Taxane Matters: Before or After?

Summary

Timeline

Publications

Drugs

Indications