drugset / Trial / NCT01271374
Changes in Endothelial Function and Biomarkers in African Americans (AA) With Metabolic Syndrome
RandomizedParallel-groupOpen-labelTreatment
Summary
The purpose of the study is to compare the effects of Azor (a combination of amlodipine and olmesartan) with Hyzaar ( a combination of losartan and hydrochlorothiazide) on the thin lining on the inside of blood vessels. These cells help keep blood vessels healthy and blood pressure normal.
Timeline
- Start
- 2010-04
- Primary completion
- 2011-06
- Completion
- 2011-12
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Amlodipine | Other / unclassified | 5 mg | — |
| Comparator | Amlodipine | Other / unclassified | 10 mg | — |
| Comparator | Hydrochlorothiazide | Unknown | 12.5 mg | — |
| Comparator | Hydrochlorothiazide | Unknown | 25 mg | — |
| Comparator | Losartan | Other / unclassified | 50 mg | — |
| Comparator | Losartan | Other / unclassified | 100 mg | — |
| Comparator | Olmesartan | Other / unclassified | 20 mg | — |
| Comparator | Olmesartan | Other / unclassified | 40 mg | — |
| Comparator | Spironolactone | Small molecule | 25 mg | — |