Topical Application of GTN 0.4% in the Treatment of Anismus Following Stapled Haemorrhoidopexy

Phase 2/3 Completed 40 enrolled University of Roma La Sapienza

RandomizedParallel-groupSingle-blindTreatment

Summary

This study wants demonstrate that the use of 0.4% nitroglycerin ointment can reduce the postoperative pain related to anorectal spasm (anismus) while performing a stapled haemorrhoidopexy.

Timeline

Start: 2004-01
Primary completion: 2010-09
Completion: 2010-12

Publications

Mari FS, Nigri G, Dall'Oglio A, Cosenza UM, Milillo A, Terrenato I, Pancaldi A, Brescia A. Topical glyceryl trinitrate ointment for pain related to anal hypertonia after stapled hemorrhoidopexy: a randomized controlled trial. Dis Colon Rectum. 2013 Jun;56(6):768-73. doi: 10.1097/DCR.0b013e31828b282c.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Lidocaine	Other / unclassified	2.5 %	Topical
Subject	Nitroglycerin	Unknown	0.4 %	Topical

Indications

No indication recorded.