drugset / Trial / NCT01285466
A Trial of Oral BEZ235 and BKM120 in Combination With Paclitaxel With or Without Trastuzumab
Non-randomizedParallel-groupOpen-labelTreatment
Summary
The purpose of the trial is to determine the maximum tolerated dose (MTD) of BEZ235 and BKM120 in combination with weekly paclitaxel and weekly paclitaxel/trastuzumab.
Timeline
- Start
- 2011-01
- Primary completion
- 2014-10
- Completion
- 2014-10
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Buparlisib | Small molecule | — | — |
| Subject | Dactolisib | Small molecule | — | — |
| Subject | Trastuzumab | Monoclonal antibody | — | — |
| Background | Paclitaxel | Small molecule | — | — |