A Study to Evaluate Sildenafil for the Treatment of Lymphatic Malformations

Summary

There is an unsatisfied medical need for a first-line treatment of lymphatic malformations with a good benefit/risk profile. Based on a patient experience in the institution, the investigators plan to verify whether or not the medication sildenafil has a beneficial effect on lymphatic malformations. The investigators plan to do this by treating patients with lymphatic malformations with the medication sildenafil for a 20 week period. This is an investigator initiated study funded by an Innovations in Patient Care grant and a SPARK grant.

Timeline

Start

2010-12

Primary completion

2013-04

Completion

2013-12

Publications

• Results Danial C, Tichy AL, Tariq U, Swetman GL, Khuu P, Leung TH, Benjamin L, Teng J, Vasanawala SS, Lane AT. An open-label study to evaluate sildenafil for the treatment of lymphatic malformations. J Am Acad Dermatol. 2014 Jun;70(6):1050-7. doi: 10.1016/j.jaad.2014.02.005. Epub 2014 Mar 20.

Drugs

Indications