Disposition of Intravenous Ketorolac

Summary

The purpose of this study is: * to document ketorolac disposition (concentration/time profile, protein binding, metabolism) and its covariates following intravenous (iv) administration of ketorolac right after caesarean section and to compare those observations (n=32) with non-pregnant state (n=8) (intra-subject PK comparison) * to document biochemical tolerance of ketorolac * to evaluate if optimalisation of ketorolac dose regimen during pregnancy and labor are appropriated and needed * to quantify the neonatal exposure to ketorolac through excretion in the breast milk

Timeline

Start

2011-06

Primary completion

2011-09

Completion

2011-09

Publications

• Kulo A, Hendrickx S, de Hoon J, Mulabegovic N, van Calsteren K, Verbesselt R, Allegaert K. The impact of pregnancy on urinary ketorolac metabolites after single intravenous bolus. Eur J Drug Metab Pharmacokinet. 2013 Mar;38(1):1-4. doi: 10.1007/s13318-012-0108-7. Epub 2012 Nov 21.

Drugs

Indications

No indication recorded.