Colistin Versus Colistin Plus Fosfomycin for Infections Caused by MDR Acinetobacter Baumannii

Phase 3 Unknown 92 enrolled Mahidol University

RandomizedParallel-groupOpen-labelTreatment

Summary

In Siriraj Hospital, colistin alone for treatment of MDR A. baumannii contributed to mortality 45% Fosfomycin is an antimicrobial which has activity against gram-negative bacterial including MDR A. baumannii In this study, we compare the clinical and microbiologicalresponse of colistin alone versus colistin plus fosfomycin in treatment of A. baumannii infected patients

Timeline

Start: 2010-06
Primary completion: 2012-05
Completion: 2012-05

Publications

Sirijatuphat R, Thamlikitkul V. Preliminary study of colistin versus colistin plus fosfomycin for treatment of carbapenem-resistant Acinetobacter baumannii infections. Antimicrob Agents Chemother. 2014 Sep;58(9):5598-601. doi: 10.1128/AAC.02435-13. Epub 2014 Jun 30.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Colistin	Other / unclassified	2.5 mg/kg	Intravenous
Comparator	Colistin	Other / unclassified	5 mg/kg	Intravenous
Comparator	Fosfomycin	Small molecule	2 g	Intravenous

Indications

No indication recorded.