drugset / Trial / NCT01299597
A Single-centre Open Label Study to Investigate the Effect of Repeat Doses of SB-649868 on the Pharmacokinetics of Simvastatin and Atorvastatin in Healthy Male Volunteers.
Non-randomizedParallel-groupOpen-labelTreatment
Summary
The present study will investigate in humans the enzyme inhibition effects of SB-649868 on CYP3A4, using Simvastatin and Atorvastatin as CYP3A4 probe substrates, administered as single doses: alone, and on two different occasions after repeat doses of SB-649868, at the same time as SB-649868 and 2h before SB-649868.
Timeline
- Start
- 2010-01-18
- Primary completion
- 2010-02-26
- Completion
- 2010-02-26
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Atorvastatin | Small molecule | 20 mg | — |
| Subject | SB-649868 | Small molecule | 20 mg | — |
| Subject | Simvastatin | Small molecule | 10 mg | — |