MK-0954A in Japanese Patients With Essential Hypertension Not Adequately Controlled With Losartan (MK-0954A-352)

Phase 3 Completed 336 enrolled Organon and Co

RandomizedParallel-groupDouble-blindTreatment

Summary

This study is being conducted to evaluate the efficacy of MK-0954A in essential hypertension participants who are not adequately controlled with losartan.

Timeline

Start: 2011-03-29
Primary completion: 2012-02-07
Completion: 2012-02-07

Outcome

Met primary endpoint

registry analysis (unspecified test); MK-0954A vs Losartan; p <.001; Difference in least square means -5.1 (95% CI -6.8 to -3.4); constrained longitudinal data analysis NCT01307046 ↗

Publications

Results Rakugi H, Tsuchihashi T, Shimada K, Numaguchi H, Nishida C, Yamaguchi H, Fujimoto G, Azuma K, Shirakawa M, Hanson ME, Fujita KP. Efficacy and safety of losartan 100 mg/hydrochlorothiazide 12.5 mg in Japanese subjects with essential hypertension: two randomized, controlled trials. Hypertens Res. 2014 Dec;37(12):1042-9. doi: 10.1038/hr.2014.114. Epub 2014 Jul 3.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Hydrochlorothiazide	Unknown	12.5 mg	Oral
Subject	Losartan	Other / unclassified	100 mg	Oral