drugset / Trial / NCT01309360
Ultrasound-guided Axillary Plexus Block - Dose Reduction of Prilocaine
Non-randomizedParallel-groupSingle-blindTreatment
Summary
Clinical aim: Does reducing the dose of local anesthetic in ultrasound-guided axillary plexus anesthesia have any effect on the success rate and additional parameters of block quality? Methodology: In this prospective cohort study three groups of 40 outpatients each were administered dosages of 1% prilocaine of either 40mL, 30mL or 20mL for axillary plexus anesthesia. Met-Hb was measured prior to administration of the block and then hourly until the Met-Hb concentration fell. Parameters of block quality and any adverse effects were recorded. The level of significance was defined with α ≤ 0.05.
Timeline
- Start
- 2009-09
- Primary completion
- 2010-04
- Completion
- 2010-04
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | prilocaine | Small molecule | 200 mg | — |
| Comparator | prilocaine | Small molecule | 300 mg | — |
| Comparator | prilocaine | Small molecule | 400 mg | — |
| Comparator | Midazolam | Small molecule | 2 mg | Oral |
| Comparator | Midazolam | Small molecule | 3 mg | Oral |
| Comparator | Midazolam | Small molecule | 3.75 mg | Oral |
| Comparator | Midazolam | Small molecule | 7.5 mg | Oral |
Indications
No indication recorded.