Drugs / prilocaine
last change Sep 2026 re-read 8 days ago

prilocaine

Small molecule

Developed for
chronic pain syndrome · hemorrhoid · cervical incompetence · diabetes mellitus · female infertility · hernia, double inguinal · osteoarthritis, knee · premature ejaculation
+6 more · shoulder impingement syndrome · stroke disorder · thalassemia · coronary vasospasm · frozen shoulder · myofascial pain syndrome
Investigated by
Cairo University · Aalborg University · Assiut University · University of Campinas, Brazil · CAMC Health System · Centre Hospitalier Universitaire Saint Pierre
+53 more · São Paulo Research Foundation · ASST Gaetano Pini-CTO · Academic Medical Center - University of Amsterdam · Ain Shams University · Ankara University · Assistance Publique - Hôpitaux de Paris · Bagcilar Training and Research Hospital · Centre Hospitalier le Mans · Colorado Clinical & Translational Sciences Institute · Dentsply International · Diskapi Teaching and Research Hospital · Dow University of Health Sciences · Dr. Pere Roura-Poch · Enrique Velasco Serna · Erasmus Medical Center · Franciscan University Center · Gustavo Adolfo Sarriá · Guy's and St Thomas' NHS Foundation Trust · Helwan University · Hippocration General Hospital · Hopital Saint Roch · Hospital General Universitario Gregorio Marañon · Indonesia Endowment Fund for Education · Indonesia University · Institue of Microengineering and Nanoelectronics (IMEN), Universiti Kebangsaan Malaysia · Loma Linda University · Lund University Hospital · Marmara University · Miguel Delicado Miralles · National Institute on Aging (NIA) · National Science and Technology Council, Taiwan · National Taiwan University Hospital · National University Hospital, Singapore · Netherlands Institute for Pigment Disorders · Obstetric Anaesthetists' Association United Kingdom · Oregon Health and Science University · Patricia Beltra Lopez · Plethora Solutions Ltd · Pontificia Universidad Catolica de Chile · Regionshospitalet Horsens · St. Mary's Research Center, Canada · Stanford University · Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey · Tanta University · Technical University of Munich · Universitas Sebelas Maret · Universiti Kebangsaan Malaysia Medical Centre · Universiti Kebangsaan Malaysia Medical Molecular Biology Institute (UMBI) · University Hospital Waterford · University Hospital, Angers · University Hospital, Montpellier · University of Aarhus · University of Colorado, Denver

Regulatory milestones approvals, filings & regulatory actions · 2 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Approved EU (EMA) Fortacin — 2013-11-15 europa.eu ↗
Approved US (FDA) CITANEST PLAIN — 1965-11-18 fda.gov ↗

Trials 56

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PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 01 trial
Phase 0 NCT05060913 Nov 2021 → Mar 2022 — Dow University of Health Sciences Completed No outcome recorded
Phase 15 trials
Phase 1 NCT05062356 Nov 2021 → Aug 2024 chronic pain syndrome St. Mary's Research Center, Canada Completed No outcome recorded
Phase 1 NCT05912335 Jun 2021 → Feb 2022 tooth disorder University of Campinas, Brazil Completed No outcome recorded
Phase 1 NCT01324843 Jun 2009 → May 2010 — National Institute on Aging (NIA) Completed No outcome recorded
Phase 1 NCT01425840 Mar → Nov 2008 — University of Campinas, Brazil Completed No outcome recorded
Phase 1 NCT01054547 Sep → Dec 2006 — University of Campinas, Brazil Completed No outcome recorded
Phase 25 trials · 1 met primary
Phase 2 NCT05078463 Sep 2021 → Aug 2022 thalassemia Universiti Kebangsaan Malaysia Medical Centre Completed No outcome recorded
Phase 2 NCT03578783 Dec 2018 → May 2021 premature ejaculation Plethora Solutions Ltd Completed No outcome recorded
Phase 2 NCT03433976 May 2018 → May 2020 — University Hospital, Montpellier Unknown Met primary
Phase 2 NCT03036384 Mar → Nov 2016 — Centre Hospitalier Universitaire Saint Pierre Completed No outcome recorded
Phase 2 NCT03607916 Feb → Aug 2014 — Centre Hospitalier Universitaire Saint Pierre Completed No outcome recorded
Phase 34 trials
Phase 3 NCT06769204 Feb → Aug 2025 overdue female infertility Cairo University Not yet recruiting No outcome recorded
Phase 3 NCT03508804 Dec 2020 → Dec 2022 — Stanford University Withdrawn No outcome recorded Stop: Business
Phase 3 NCT02130830 May 2014 → May 2016 hemorrhoid Pontificia Universidad Catolica de Chile Completed No outcome recorded
Phase 3 NCT00959595 Nov 2008 → Jan 2010 diabetes mellitus Lund University Hospital Completed No outcome recorded
Phase 423 trials
Phase 4 NCT06767085 Feb → Jul 2025 overdue — Cairo University Not yet recruiting No outcome recorded
Phase 4 NCT07329582 May 2024 → Dec 2025 overdue — National University Hospital, Singapore Active not recruiting No outcome recorded
Phase 4 NCT06133881 Dec 2023 → Feb 2024 — Cairo University Completed No outcome recorded
Phase 4 NCT05970354 Sep 2023 → Nov 2024 — CAMC Health System Completed No outcome recorded
Phase 4 NCT05834647 Aug → Nov 2023 local anesthetic poisoning Universitas Sebelas Maret Unknown No outcome recorded
Phase 4 NCT05984264 Jan → Sep 2023 — Assiut University Unknown No outcome recorded
Phase 4 NCT05649020 Nov 2022 → Dec 2023 — Hospital General Universitario Gregorio Marañon Unknown No outcome recorded
Phase 4 NCT05610007 Jan → Aug 2022 — Indonesia University Unknown No outcome recorded
Phase 4 NCT04394533 Aug 2021 → Aug 2025 cervical incompetence Guy's and St Thomas' NHS Foundation Trust Completed No outcome recorded
Phase 4 NCT04355598 Apr → Aug 2020 — Cairo University Unknown No outcome recorded
Phase not applicable18 trials · 1 missed
— NCT07683182 Nov 2025 → Jun 2026 overdue — Marmara University Active not recruiting No outcome recorded
— NCT06891794 Aug 2025 → Apr 2026 overdue uterine inflammatory disease Oregon Health and Science University Recruiting No outcome recorded
— NCT07034456 Jul 2025 → Jan 2026 overdue — Patricia Beltra Lopez Not yet recruiting No outcome recorded
— NCT06600048 Sep 2024 → Mar 2025 — Tanta University Completed No outcome recorded
— NCT07664618 Apr 2024 → May 2025 — Helwan University Completed No outcome recorded
— NCT05877690 Oct 2023 → Oct 2024 — Assiut University Unknown No outcome recorded
— NCT05926895 Jun 2023 → Aug 2024 shoulder impingement syndrome Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey Completed No outcome recorded
— NCT06274905 Feb → Jul 2023 head and neck cancer, skin neoplasm University Hospital Waterford Completed No outcome recorded
— NCT07156968 Jan 2022 → Feb 2023 — Ain Shams University Completed No outcome recorded
— NCT05195177 Nov 2021 → Dec 2023 — Aalborg University Unknown No outcome recorded
Comparator or background therapy65 trials
Phase 0 NCT06680167 Comparator Oct 2024 → Nov 2025 — Sohag University Completed No outcome recorded
Phase 0 NCT02427724 Comparator Apr 2015 → May 2024 lentigo Northwestern University Completed No outcome recorded
Phase 1 NCT03313336 Comparator Oct → Nov 2017 — AstraZeneca Completed No outcome recorded
Phase 1 NCT03441841 Comparator Feb → Mar 2016 — Galeno Desenvolvimento de Pesquisas Clínicas Completed No outcome recorded
Phase 1 NCT03325803 Background Sep 2015 → Sep 2016 actinic keratosis Dong-A University Completed No outcome recorded

Evidence & citations 26 cited values

Every value below carries the sentence it was read from. 123 sources stand behind the page.

FieldValueCited text
Known as prilocaine “EMLA Cream (Eutectic Mixture of Local Anesthetics) is an FDA-approved topical anesthetic comprised of 2.5% each of lidocaine/prilocaine. EMLA Cream was applied in approximately...” NCT00444626 ↗
117

“transrectal ultrasound guided 10 ml prilocaine and serum physiologic blend (5ml %2 prilocaine and 5 ml serum physiologic) injected separetly 5ml right and 5ml left junction...” NCT02025361 ↗

“The EMLA group received EMLA cream which consisted of 2.5% lidocaine and 2.5 % prilocaine in 2 ml of water/oil emulsion and then they received tegaderm as the dressing for...” NCT03134391 ↗

“At the start of session 2, one area of the middle forearms of the participant will be located (4x4cm). On the area, local anesthetic cream (2.5% lidocain/2.5 prilocaine) will...” NCT05195177 ↗

“EMLA®, a topical anesthetic cream containing lidocaine and prilocaine, will be applied under occlusion prior to tape application during 30 minutes with the aim of anesthetize...” NCT07034456 ↗

“liposome-encapsulated 2% ropivacaine, liposome-encapsulated 1% ropivacaine, a eutectic mixture of 2.5% lidocaine and 2.5% prilocaine (EMLA), and liposomal placebo gel,...” PMID 21106282 ↗ Nov 2010

“100 mg of the following formulations: Liposome-encapsulated 2,5% and 5% lidocaine gel, liposome placebo gel and 2.5% lidocaine and 2.5% prilocaine cream were applied once...” NCT01425840 ↗

“The purpose of this study is to compare the effects of vapocoolant spray and topical lidocaine 2.5% + prilocaine 2.5% cream (EMLA) on reducing pain during needle electromyography.” NCT01606046 ↗

“EMLA cream 5% 25g lidocaine, 25g prilocaine; Astra Zeneca. Topically applied followed by Tegaderm dressing to cover. Length of duration monitored and recorded as part of study” NCT06274905 ↗

“standard EMLA patch which is a eutectic emulsion mixture of lidocaine and prilocaine at 1:1 ratio (i.e. each gram of EMLA cream contains lidocaine and prilocaine, 25 mg each).” NCT05694858 ↗

“a local anaesthetic cream consisting of equal parts of lidocaine and prilocaine (1g contains 25 mg of lidocaine and 25 mg of prilocaine, AstraZeneca A/S, Albertslund, Denmark)” NCT04076865 ↗

Show 107 more sources

Known as ASTRA 1512 ChEMBL registry synonym — accepted as the source's own label CHEMBL1194 ↗
Known as ASTRA-1515 ChEMBL registry synonym — accepted as the source's own label CHEMBL1194 ↗
Known as citanest ClinicalTrials.gov intervention name — accepted as the source's own label NCT01412632 ↗
Known as Citanest hydrochloride ChEMBL registry synonym — accepted as the source's own label CHEMBL1194 ↗
Known as Citanest plain ChEMBL registry synonym — accepted as the source's own label CHEMBL1194 ↗
Known as Citanest plain dental ChEMBL registry synonym — accepted as the source's own label CHEMBL1194 ↗
Known as L-67 HYDROCHLORIDE ChEMBL registry synonym — accepted as the source's own label CHEMBL1194 ↗
Known as NSC-40027 ChEMBL registry synonym — accepted as the source's own label CHEMBL1194 ↗
Known as NSC-758432 ChEMBL registry synonym — accepted as the source's own label CHEMBL1194 ↗
Known as Priloc “Injection of 1 CC Betamethasone Dipropionate + Betamethasone Sodium Phosphate (Diprospan) and 4 cc 2% Prilocaine (Priloc)mixture into the subacromial space” NCT05926895 ↗
Known as Priloc %2 “Autologous Blood Injection group were administered 1ml of autologous venous blood mixed with 2ml of 2% prilocaine HCl(Priloc %2,Vem,Turkey) subcutaneously.” NCT06236178 ↗
Known as Priloc HCl %2 “20 ml of bupivacaine(Buvicaine HCl %0.5) and prilocaine(Priloc HCl %2) 1:1 mixture” NCT04756050 ↗
Known as Prilocaina ChEMBL registry synonym — accepted as the source's own label CHEMBL1194 ↗
Known as Prilocaine component of emla ChEMBL registry synonym — accepted as the source's own label CHEMBL1194 ↗
Known as Prilocaine component of fortacin ChEMBL registry synonym — accepted as the source's own label CHEMBL1194 ↗
Known as Prilocaine component of oraqix ChEMBL registry synonym — accepted as the source's own label CHEMBL1194 ↗
Known as Prilocaine HCl “Those in the AB group were administered 1 ml of autologous venous blood mixed with 2 ml of 2% prilocaine HCl.” PMID 38963583 ↗ Jul 2024
1

“EPINEPHrine 1:200,000 / Prilocaine HCl 4 % 1.8 ML Cartridge” NCT05062356 ↗

Known as prilocaine hydrochloride “prilocaine 2% (Takipril, prilocaine hydrochloride 20 mg/mL, hyperbar, Sintetica)” NCT05726968 ↗
2

“prilocaine 2% (Takipril, prilocaine hydrochloride 20 mg/mL, hyperbar, Sintetica)” NCT06133881 ↗

NCT05668286 ↗

Known as Propitocaine ChEMBL registry synonym — accepted as the source's own label CHEMBL1194 ↗
Known as Propitocaine hydrochloride ChEMBL registry synonym — accepted as the source's own label CHEMBL1194 ↗
Known as Takipril “40 mg (low dose) intrathecal hyperbaric prilocaine 2% (Takipril, Sunny Medical group, Egypt under liscense from Sintetica, Switzerland)” NCT06382220 ↗
2

“prilocaine 2% (Takipril, prilocaine hydrochloride 20 mg/mL, hyperbar, Sintetica)” NCT05726968 ↗

“prilocaine 2% (Takipril, prilocaine hydrochloride 20 mg/mL, hyperbar, Sintetica)” NCT06133881 ↗

Known as Xylonest ChEMBL registry synonym — accepted as the source's own label CHEMBL1194 ↗
Action Inhibit “This lidocaine/prilocaine preparation blocks sodium channels in peripheral nerves in the skin” NCT05289804 ↗
Modality Small molecule — CHEMBL1194 ↗