Metformin for the Treatment of Premature Pubarche in Girls

Summary

The primary objective of this study is to determine the safety and efficacy of metformin in lowering serum DHEAS levels in girls with premature pubarche and secondary, to observe changes in hormones associated with pubertal development including gonadotropins, sex steroids, insulin, adipocytokines, and growth factors.

Timeline

Start

2011-05

Primary completion

2013-12

Completion

2014-04

Outcome

Outcome not reported

Stopped (Enrollment): “poor recruitment at collaborating sites”

Drugs

Indications