drugset / Trial / NCT01318044

Thiopental Versus Propofol During Magnetic Resonance Imagining in Children: Something Old, Something New

NCT01318044

Phase 1/2 Unknown 100 enrolled University Clinical Centre of Kosova
RandomizedParallel-groupTriple-blindTreatment

Summary

Magnetic resonance imagining (MRI) in children requires sedation to achieve the degree of cooperation or immobilization, necessary to complete these procedures successfully. In this study the investigators analyze two most popular anesthetics used for this procedure, sodium thiopental and propofol. The aim of this study is to determine optimal dose of propofol and thiopental during MRI and to establish safety and efficacy of these drugs.

Timeline

Start
2011-01
Primary completion
2011-04
Completion
2011-05

Publications

  • Background 1. Malvija S, Voepel -Lewis T, Eldevik OP, Rockwell DT, Wong JH, Tait AR. Sedation and general anaesthesia in children undergoing MRI and CT: adverse events and outcomes. Br J A naesth 2000; 84: 743-8. 2. Malviya S, Voepel-Lewis T, Tait AR, Merkel S, Tremper K, Naughton N. Depth of sedation in children undergoing computed tomography: validity and reliability of the University of Michigan Sedation Scale (UMSS). Br J Anaesth. 2002 ;88:241-5. 3. Koroglu A, Teksan H, Sagir O, Yucel A, Toprak HI, Ersoy OM. A comparison of the sedative, hemodynamic, and respiratory effects of dexmedetomidine and propofol in children undergoing magnetic resonance imaging. Anesth Analg. 2006;103:63-7.

Drugs

EvaluationDrugModalityDoseRoute
Comparator Propofol Small molecule 0.5 mg/kg Intravenous
Comparator Thiopental Small molecule 2 mg/kg Intravenous

Indications

No indication recorded.