drugset / Trial / NCT01320982
Minocycline, Acetylsalicylic Acid or Pramipexole vs Placebo in Patients With Schizophrenia or Schizoaffective Disorder
RandomizedParallel-groupTriple-blindTreatment
Summary
The objective of the study is to evaluate the efficacy of Pramipexole, Minocycline and Aspirin compared to placebo, as add-on to anti-psychotics in the treatment of patients with schizophrenia.
Timeline
- Start
- 2011-03
- Primary completion
- 2012-06
- Completion
- 2012-07
Publications
- Levi L, Zamora D, Nastas I, Gonen I, Radu P, Matei V, Ciobanu AM, Nacu A, Boronin L, Karakrah L, Davidson M, Davis JM, Weiser M. Add-On Pramipexole for the Treatment of Schizophrenia and Schizoaffective Disorder: A Randomized Controlled Trial. J Clin Psychiatry. 2022 Aug 1;83(5):21m14233. doi: 10.4088/JCP.21m14233.
- Weiser M, Zamora D, Levi L, Nastas I, Gonen I, Radu P, Matei V, Nacu A, Boronin L, Davidson M, Davis JM. Adjunctive Aspirin vs Placebo in Patients With Schizophrenia: Results of Two Randomized Controlled Trials. Schizophr Bull. 2021 Jul 8;47(4):1077-1087. doi: 10.1093/schbul/sbaa198.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Aspirin | Small molecule | 500 mg | — |
| Comparator | Minocycline | Small molecule | 100 mg | — |
| Comparator | Pramipexole | Unknown | 0.125 mg | — |
| Comparator | Pramipexole | Unknown | 0.25 mg | — |
| Comparator | Pramipexole | Unknown | 0.5 mg | — |
| Comparator | Pramipexole | Unknown | 0.75 mg | — |