Dexamethasone for the Prevention of Postoperative Cognitive Dysfunction

Phase 4 Completed 300 enrolled University of Sao Paulo Duke University · collab Fundação de Amparo à Pesquisa do Estado de São Paulo · collab

RandomizedParallel-groupTriple-blindPrevention

Summary

This study aims to evaluate the possible effect of dexamethasone on prevention of cognitive dysfunction in the postoperative period of elderly patients undergoing to surgery under general anesthesia.

Timeline

Start: 2011-01
Primary completion: 2013-02
Completion: 2013-03

Outcome

Met primary endpoint

paper Neuropsychological tests showed that dexamethasone associated to BIS 46-55 decreased the incidence of POCD, especially memory and executive function. PMID 27152422 ↗

paper Dexamethasone can reduce the incidence of POCD in elderly patients undergoing surgery, especially when associated with BIS 46-55. PMID 27152422 ↗

Publications

Valentin LS, Pereira VF, Pietrobon RS, Schmidt AP, Oses JP, Portela LV, Souza DO, Vissoci JR, Luz VF, Trintoni LM, Nielsen KC, Carmona MJ. Effects of Single Low Dose of Dexamethasone before Noncardiac and Nonneurologic Surgery and General Anesthesia on Postoperative Cognitive Dysfunction-A Phase III Double Blind, Randomized Clinical Trial. PLoS One. 2016 May 6;11(5):e0152308. doi: 10.1371/journal.pone.0152308. eCollection 2016.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Dexamethasone	Small molecule	8 mg	Intravenous

Indications

No indication recorded.