Effect of Intravenous Lidocaine on the Tolerability of Early Oral Feeding After Laparoscopic Colorectal Surgery

Summary

The purpose of this study is to determine whether intravenous lidocaine increase the tolerability of early oral feeding after laparoscopic colorectal surgery in patients with colorectal cancer. * Degree of nausea/vomiting. * Degree of postoperative pain and opioids requirement. * Time to first flatus, time to first stool, time to tolerance of regular diet, rate of postoperative complications and duration of postoperative hospital stay.

Timeline

Start

2011-04

Primary completion

2012-06

Completion

2012-06

Outcome

Missed primary endpoint

paper Postoperative nausea and vomiting were higher in the control group but did not reach statistical significance (P = 0.054). PMID 24612414 ↗

paper Tolerability of EOF was 96.9% in the lidocaine group and 91.7% in the control group (P = 0.62). PMID 24612414 ↗

Publications

• Kim HO, Lee SR, Choi WJ, Kim H. Early oral feeding following laparoscopic colorectal cancer surgery. ANZ J Surg. 2014 Jul-Aug;84(7-8):539-44. doi: 10.1111/ans.12550. Epub 2014 Feb 24.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Lidocaine	Other / unclassified	1 mg/kg	Intravenous

Indications