Effects of Iron Loading and Iron Chelation Therapy on Innate Immunity During Human Endotoxemia

Summary

Iron affects immunity. However, the exact effect of iron on the innate immune response is not known. Animal data suggest that iron administration induced oxidative stress which enhances the innate immune response, whereas iron chelation has the opposite effect. The investigators tested the hypothesis that administration of iron sucrose 1.25 mg/kg augments the innate immune response, and iron chelation by deferasirox 30 mg/kg attenuates the innate immune response during human experimental endotoxemia.

Timeline

Start

2010-02

Primary completion

2010-05

Completion

2010-09

Drugs

Indications