drugset / Trial / NCT01373463

Cisplatin and Pemetrexed With Radiation Followed by Lobectomy

NCT01373463

Phase 1 Terminated 48 enrolled Medical University of South Carolina
Non-randomizedOpen-labelTreatment

Summary

This study is open to patients that have been diagnosed with non-squamous Stage III Non Small Cell Lung Cancer (NSCLC) and will have surgery to remove the tumor. The purpose of this study is to: * Test a combination of two chemotherapeutic drugs along with radiation therapy, when given prior to surgery and see what effects (good or bad) it has on someone with this type of cancer. Chemotherapeutic drugs selectively destroy diseased cancer cells and tissues. * Test the safety of different dose levels of radiation when given with each combination of chemotherapy; * Determine what side effects are associated with combining radiation with these two chemotherapy combinations.

Timeline

Start
2011-05
Primary completion
2012-06
Completion
2012-06

Drugs

EvaluationDrugModalityDoseRoute
Subject Carboplatin Small molecule Intravenous
Subject Cisplatin Other / unclassified Intravenous
Background Pemetrexed Small molecule Intravenous