Drugs / Pemetrexed
last change yesterday re-read 8 days ago

Pemetrexed

Small molecule targets DHFR, GART, TYMS via inhibition

Developed for
non-small cell lung carcinoma · lung cancer · cancer · malignant pleural mesothelioma · lung adenocarcinoma · breast cancer · colorectal cancer · mesothelioma
+115 more · small cell lung carcinoma · neoplastic meningitis · urothelial carcinoma · head and neck cancer · malignant leptomeningeal tumor · ovarian cancer · cancer of unknown primary site · metastatic malignant neoplasm · metastatic neoplasm · metastatic malignant neoplasm in the brain · colorectal neoplasm · head and neck squamous cell carcinoma · lung carcinoma · malignant mesothelioma · primary peritoneal carcinoma · endometrial cancer · lung neoplasm · pancreatic ductal adenocarcinoma · peritoneum cancer · sarcoma · adenocarcinoma · central nervous system neoplasm · cervical cancer · esophageal cancer · gastric cancer · head and neck neoplasm · lymphoma · malignant pancreatic neoplasm · malignant peritoneal mesothelioma · neoplasm · ovarian carcinoma · squamous cell lung carcinoma · biliary tract cancer · central nervous system non-hodgkin lymphoma · chordoma · fallopian tube cancer · gastric neoplasm · lung large cell carcinoma · malignant tumor of meninges · melanoma · non-small cell squamous lung carcinoma · osteosarcoma · ovarian neoplasm · pancreatic neoplasm · pleural epithelioid mesothelioma · pleural mesothelioma · prostate cancer · soft tissue sarcoma · transitional cell carcinoma · urinary bladder cancer · acute myeloid leukemia, KRAS gene mutation · bile duct cancer · breast carcinoma · breast neoplasm · carcinoma of esophagus · central nervous system cancer · cervical adenosquamous carcinoma · childhood malignant neoplasm · childhood medulloblastoma · choriocarcinoma · colon carcinoma · diffuse large B-cell lymphoma · digestive system neoplasm · ependymoma · Ewing sarcoma · exocrine pancreatic carcinoma · fallopian tube carcinoma · female breast carcinoma · gallbladder cancer · gastric carcinoma · gastroesophageal cancer · gestational trophoblastic neoplasm · high grade astrocytic tumor · high grade malignant neoplasm · hormone-resistant prostate carcinoma · hydatidiform mole · infiltrating bladder urothelial carcinoma sarcomatoid variant · liver cancer · major salivary gland carcinoma · malignant biphasic mesothelioma · malignant glioma · medulloblastoma · metastatic carcinoma · micropapillary variant infiltrating bladder urothelial carcinoma · nasopharyngeal carcinoma · neoplasm of esophagus · neoplastic disease or syndrome · neuroblastoma · neuroendocrine neoplasm · peritoneal carcinomatosis · plasmacytoid variant infiltrating bladder urothelial carcinoma · pleural neoplasm · primary central nervous system lymphoma · prostate carcinoma · rectal cancer · rectal neoplasm · refractory malignant neoplasm · renal cell carcinoma · renal pelvis/ureter urothelial carcinoma · RET fusion positive cancer · rhabdomyosarcoma · salivary gland adenoid cystic carcinoma · sarcomatoid mesothelioma · squamous cell carcinoma · thymic carcinoma · thymoma · thyroid cancer · thyroid gland carcinoma · tumor of salivary gland · ureter cancer · urethra cancer · urinary bladder carcinoma · colon adenocarcinoma · female reproductive system neoplasm · rectum adenocarcinoma
Investigated by
Eli Lilly and Company · National Cancer Institute (NCI) · Merck Sharp & Dohme LLC · AstraZeneca · Bristol-Myers Squibb · Genentech, Inc.
+400 more · Sun Yat-sen University · M.D. Anderson Cancer Center · Alliance for Clinical Trials in Oncology · Fudan University · Cancer Institute and Hospital, Chinese Academy of Medical Sciences · Memorial Sloan Kettering Cancer Center · Gynecologic Oncology Group · Hunan Province Tumor Hospital · Yonsei University · French Cooperative Thoracic Intergroup · Guangzhou Medical University · Henan Cancer Hospital · Shanghai Chest Hospital · Shanghai Junshi Bioscience Co., Ltd. · Shanghai Pulmonary Hospital, Shanghai, China · Columbia University · GlaxoSmithKline · Hoffmann-La Roche · Jiangsu Hansoh Pharmaceutical Co., Ltd. · Northwestern University · Pfizer · Regeneron Pharmaceuticals · Sanofi · Tianjin Medical University Cancer Institute and Hospital · Fujian Cancer Hospital · Massachusetts General Hospital · Mayo Clinic · SCRI Development Innovations, LLC · SWOG Cancer Research Network · Samsung Medical Center · UNC Lineberger Comprehensive Cancer Center · AbbVie · Akeso · Barbara Ann Karmanos Cancer Institute · BeiGene · Brigham and Women's Hospital · Dana-Farber Cancer Institute · H. Lee Moffitt Cancer Center and Research Institute · Hellenic Oncology Research Group · Innovent Biologics (Suzhou) Co. Ltd. · Novartis Pharmaceuticals · Sichuan Cancer Hospital and Research Institute · Tang-Du Hospital · The First Affiliated Hospital with Nanjing Medical University · The First Hospital of Jilin University · University of Arizona · Wake Forest University Health Sciences · Washington University School of Medicine · Asan Medical Center · Bayer · Chia Tai Tianqing Pharmaceutical Group Co., Ltd. · Chinese Academy of Medical Sciences · Eastern Cooperative Oncology Group · European Organisation for Research and Treatment of Cancer - EORTC · Guangdong Association of Clinical Trials · Janssen Research & Development, LLC · Jiangsu HengRui Medicine Co., Ltd. · Jonsson Comprehensive Cancer Center · Novartis · Radboud University Medical Center · Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · University Health Network, Toronto · University Hospital of Crete · University of California, Davis · University of Chicago · University of Pittsburgh · Vanderbilt-Ingram Cancer Center · Virginia Commonwealth University · West China Hospital · Zhejiang Cancer Hospital · ZonMw: The Netherlands Organisation for Health Research and Development · AIO-Studien-gGmbH · Affiliated Hospital of Guangdong Medical University · Albert Einstein College of Medicine · all 406 on the full record

Regulatory milestones approvals, filings & regulatory actions · 12 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Label expansion US (FDA) AXTLE — 2025-10-03 fda.gov ↗
Label expansion US (FDA) PEMETREXED — 2022-11-22 fda.gov ↗
Label expansions (8) US (FDA) ALIMTA — 2008-09-26 – 2022-08-31 fda.gov ↗
Approved EU (EMA) Alimta — 2004-09-20 europa.eu ↗
Approved US (FDA) ALIMTA — 2004-02-04 fda.gov ↗

Trials 690 · started per year

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PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 05 trials
Phase 0 NCT06208033 Jan → Oct 2024 non-small cell lung carcinoma Fujian Cancer Hospital Unknown No outcome recorded
Phase 0 NCT05459441 Jan 2022 → Jun 2023 glioma, metastatic malignant neoplasm in the brain Shanghai Pudong Hospital Unknown No outcome recorded
Phase 0 NCT04220892 Jul 2020 high grade astrocytic tumor Jose Carrillo Withdrawn No outcome recorded
Phase 0 NCT02568033 Oct 2013 → Oct 2017 non-small cell lung carcinoma The Cooper Health System Unknown No outcome recorded
Phase 0 NCT00424242 Jan 2007 → Jan 2010 cancer of unknown primary site, central nervous system neoplasm, leukemia, lymphoproliferative syndrome +5 Northwestern University Completed No outcome recorded
Phase 186 trials · 1 met primary
Phase 1 NCT06946927 Jun 2025 → Feb 2026 overdue non-small cell lung carcinoma Jemincare Recruiting No outcome recorded
Phase 1 NCT06917079 Mar 2025 → Aug 2027 expected colorectal cancer, non-small cell lung carcinoma, pancreatic ductal adenocarcinoma TheRas, Inc., d/b/a BBOT (BridgeBio Oncology Therapeutics) Recruiting No outcome recorded
Phase 1 NCT06835569 Mar 2025 → May 2029 expected colorectal cancer, non-small cell lung carcinoma, pancreatic ductal adenocarcinoma Alterome Therapeutics, Inc. Recruiting No outcome recorded
Phase 1 NCT06621563 Dec 2024 → Mar 2026 overdue colorectal cancer, non-small cell lung carcinoma Hansoh BioMedical R&D Company Recruiting No outcome recorded
Phase 1 NCT06704724 Dec 2024 → May 2026 colorectal neoplasm, non-small cell lung carcinoma, pancreatic ductal adenocarcinoma Pfizer Terminated No outcome recorded Stop: Business
Phase 1 NCT06663306 Dec 2024 → Dec 2027 expected neoplastic meningitis, non-small cell lung carcinoma Shanghai Chest Hospital Recruiting No outcome recorded
Phase 1 NCT06594874 Oct 2024 → Oct 2026 expected non-small cell lung carcinoma Jiangsu Hansoh Pharmaceutical Co., Ltd. Not yet recruiting No outcome recorded
Phase 1 NCT06561685 Sep 2024 → Oct 2027 expected metastatic neoplasm, non-small cell lung carcinoma Eli Lilly and Company Recruiting No outcome recorded
Phase 1 NCT06333951 Sep 2024 → Oct 2026 expected non-small cell lung carcinoma Amgen Active not recruiting No outcome recorded
Phase 1 NCT06447662 Jun 2024 → Oct 2026 expected colorectal neoplasm, non-small cell lung carcinoma, pancreatic ductal adenocarcinoma Pfizer Active not recruiting No outcome recorded
Phase 1/262 trials
Phase 1/2 NCT07594626 Dec 2027 → Dec 2030 expected biliary tract cancer, carcinoma of esophagus, colon carcinoma, metastatic carcinoma Northwestern University Not yet recruiting No outcome recorded
Phase 1/2 NCT07354061 Mar 2026 → Mar 2028 expected non-small cell lung carcinoma Tang-Du Hospital Recruiting No outcome recorded
Phase 1/2 NCT07472647 Feb 2026 → Feb 2029 expected non-small cell lung carcinoma, small cell lung carcinoma Shanghai JMT-Bio Inc. Not yet recruiting No outcome recorded
Phase 1/2 NCT07397338 Jan 2026 → May 2029 expected colorectal cancer, metastatic neoplasm, non-small cell lung carcinoma Revolution Medicines, Inc. Recruiting No outcome recorded
Phase 1/2 NCT06462092 Jan 2026 → Jan 2027 expected malignant leptomeningeal tumor Guangzhou Medical University Recruiting No outcome recorded
Phase 1/2 NCT06405230 Oct 2025 → Jul 2026 non-small cell lung carcinoma GlaxoSmithKline Terminated No outcome recorded
Phase 1/2 NCT07121374 Jul 2025 → Jun 2028 expected pleural epithelioid mesothelioma University Hospital, Antwerp Recruiting No outcome recorded
Phase 1/2 NCT07070440 Jul 2025 → Jun 2027 expected non-small cell lung carcinoma Dizal Pharmaceuticals Recruiting No outcome recorded
Phase 1/2 NCT06943820 May 2025 → Dec 2026 expected colorectal adenocarcinoma, head and neck squamous cell carcinoma, non-small cell lung carcinoma Akeso Recruiting No outcome recorded
Phase 1/2 NCT06809517 Mar 2025 → Mar 2026 overdue neoplastic meningitis Guangzhou Medical University Recruiting No outcome recorded
Phase 2422 trials · 9 met primary · 22 missed
Phase 2 NCT07229339 Jun 2027 → Jun 2029 expected non-small cell lung carcinoma Jonsson Comprehensive Cancer Center Not yet recruiting No outcome recorded
Phase 2 NCT07845916 Oct 2026 → Jun 2027 expected non-small cell lung carcinoma Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Not yet recruiting No outcome recorded
Phase 2 NCT07858253 Oct 2026 → Oct 2030 expected lung carcinoma Anusha Chidharla, MD Not yet recruiting No outcome recorded
Phase 2 NCT07807722 Sep 2026 → Mar 2028 expected non-small cell lung carcinoma Hubei Cancer Hospital Not yet recruiting No outcome recorded
Phase 2 NCT07586202 Jul 2026 → Mar 2028 expected non-small cell lung carcinoma Janssen Research & Development, LLC Recruiting No outcome recorded
Phase 2 NCT07492680 Jul 2026 → Aug 2028 expected cancer Bristol-Myers Squibb Recruiting No outcome recorded
Phase 2 NCT07709585 Jul 2026 → Jul 2030 expected non-small cell lung carcinoma Guangzhou University of Traditional Chinese Medicine Not yet recruiting No outcome recorded
Phase 2 NCT07624487 Jun 2026 → Dec 2028 expected lung adenocarcinoma Taipei Medical University Hospital Recruiting No outcome recorded
Phase 2 NCT07661173 Jun 2026 → Mar 2029 expected non-small cell lung carcinoma Anhui Provincial Cancer Hospital Not yet recruiting No outcome recorded
Phase 2 NCT07551414 May 2026 → May 2027 expected neoplastic meningitis, non-small cell lung carcinoma Cancer Institute and Hospital, Chinese Academy of Medical Sciences Not yet recruiting No outcome recorded
Show all 422 trials opens the full record — a long page
Phase 2/37 trials · 1 met primary
Phase 2/3 NCT07005102 Aug 2025 → Nov 2036 expected non-small cell lung carcinoma AbbVie Recruiting No outcome recorded
Phase 2/3 NCT07131319 Apr 2025 → Oct 2028 expected non-small cell lung carcinoma Second Affiliated Hospital of Nanchang University Recruiting No outcome recorded
Phase 2/3 NCT05255302 May 2022 → May 2025 overdue non-small cell lung carcinoma French Cooperative Thoracic Intergroup Recruiting No outcome recorded
Phase 2/3 NCT05209256 Mar 2022 → Jan 2024 non-small cell lung carcinoma The First Affiliated Hospital of Henan University of Science and Technology Unknown No outcome recorded
Phase 2/3 NCT03380468 Jan 2018 → Jan 2024 lung neoplasm Fudan University Unknown No outcome recorded
Phase 2/3 NCT03178552 Sep 2017 → Jun 2027 expected non-small cell lung carcinoma Hoffmann-La Roche Active not recruiting Mixed
Phase 2/3 NCT00775385 Apr 2009 → Apr 2013 non-small cell lung carcinoma French Cooperative Thoracic Intergroup Completed Met primary
Phase 375 trials · 13 met primary · 16 missed
Phase 3 NCT07715396 Oct 2026 → Oct 2031 expected non-small cell lung carcinoma AIO-Studien-gGmbH Not yet recruiting No outcome recorded
Phase 3 NCT07526792 Jun 2026 → Jun 2029 expected urothelial carcinoma CSPC Megalith Biopharmaceutical Co.,Ltd. Not yet recruiting No outcome recorded
Phase 3 NCT07554846 May 2026 → May 2030 expected — Fudan University Recruiting No outcome recorded
Phase 3 NCT07154368 Sep 2025 → Oct 2027 expected non-small cell lung carcinoma Guangzhou JOYO Pharma Co., Ltd Not yet recruiting No outcome recorded
Phase 3 NCT06632327 Dec 2024 → Apr 2029 expected non-small cell lung carcinoma Alliance for Clinical Trials in Oncology Active not recruiting No outcome recorded
Phase 3 NCT06417814 Oct 2024 → Sep 2026 overdue non-small cell lung carcinoma AstraZeneca Recruiting No outcome recorded
Phase 3 NCT06485557 Aug 2024 → Dec 2025 overdue non-small cell lung carcinoma Tang-Du Hospital Not yet recruiting No outcome recorded
Phase 3 NCT06096844 Jul 2024 → Apr 2039 expected non-small cell lung carcinoma National Cancer Institute (NCI) Recruiting No outcome recorded
Phase 3 NCT06093503 May 2024 → Apr 2028 non-small cell lung carcinoma AbbVie Withdrawn No outcome recorded Stop: Business
Phase 3 NCT06382116 May 2024 → May 2026 overdue non-small cell lung carcinoma Sichuan Baili Pharmaceutical Co., Ltd. Active not recruiting No outcome recorded
Phase 417 trials · 1 met primary · 1 missed
Phase 4 NCT07279935 May 2026 → May 2030 expected non-small cell lung carcinoma AstraZeneca Recruiting No outcome recorded
Phase 4 NCT07092202 Apr 2025 → May 2027 expected malignant leptomeningeal tumor, non-small cell lung carcinoma Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Recruiting No outcome recorded
Phase 4 NCT06357598 Jan → Dec 2024 non-small cell lung carcinoma The Affiliated Hospital of Qingdao University Unknown No outcome recorded
Phase 4 NCT06230055 Jan 2024 → Jan 2026 overdue Her2-receptor negative breast cancer, malignant leptomeningeal tumor Fudan University Recruiting No outcome recorded
Phase 4 NCT03656549 Feb 2019 → Dec 2023 mesothelioma, non-small cell lung carcinoma Radboud University Medical Center Completed No outcome recorded
Phase 4 NCT03655821 Feb 2019 → May 2021 mesothelioma, non-small cell lung carcinoma Radboud University Medical Center Terminated Missed primary
Phase 4 NCT03655834 Feb 2019 → Sep 2020 mesothelioma, non-small cell lung carcinoma Radboud University Medical Center Completed No outcome recorded
Phase 4 NCT03792503 Feb 2019 → Feb 2020 non-small cell lung carcinoma Xinqiao Hospital of Chongqing Withdrawn No outcome recorded
Phase 4 NCT03768037 Nov 2018 → Nov 2019 non-small cell lung carcinoma Guangdong Association of Clinical Trials Unknown No outcome recorded
Phase 4 NCT03460678 Feb → Nov 2018 non-small cell lung carcinoma Hikma Pharmaceuticals LLC Terminated No outcome recorded Stop: Enrollment
Phase not applicable15 trials
— NCT07542912 Jun 2026 → Jun 2029 expected — Sun Yat-sen University Not yet recruiting No outcome recorded
— NCT07538193 May 2026 → May 2029 expected metastatic malignant neoplasm in the lymph nodes, non-small cell lung carcinoma Tang-Du Hospital Not yet recruiting No outcome recorded
— NCT07398599 Feb 2026 → Dec 2027 expected malignant leptomeningeal tumor, non-small cell lung carcinoma Second Affiliated Hospital of Nanchang University Recruiting No outcome recorded
— NCT06643000 Dec 2024 → Mar 2025 overdue malignant tumor of meninges, non-small cell lung carcinoma Henan Cancer Hospital Recruiting No outcome recorded
— NCT06576635 Dec 2024 → Sep 2026 overdue non-small cell lung carcinoma University of Illinois at Chicago Recruiting No outcome recorded
— NCT06304441 Apr 2024 → Jun 2026 overdue neoplastic meningitis Guangzhou Medical University Recruiting No outcome recorded
— NCT05305885 Aug 2022 → Oct 2023 neoplastic meningitis The First Hospital of Jilin University Unknown No outcome recorded
— NCT05527808 Aug 2022 → Jun 2025 lung adenocarcinoma Jun Liu Unknown No outcome recorded
— NCT04970043 Jul 2021 → Jul 2024 lung carcinoma Cancer Institute and Hospital, Chinese Academy of Medical Sciences Unknown No outcome recorded
— NCT03671538 Oct 2018 → Aug 2019 non-small cell lung carcinoma Lingyu Luo Unknown No outcome recorded
Phase not stated1 trial
— NCT00040625 — mesothelioma Eli Lilly and Company Approved for marketing No outcome recorded
Comparator or background therapy635 trials
Phase 1 NCT07699757 Background Jul 2026 → Apr 2029 expected non-small cell lung carcinoma, pancreatic ductal adenocarcinoma Haisco Pharmaceutical Group Co., Ltd. Not yet recruiting No outcome recorded
Phase 1 NCT07608731 Background Jun 2026 → Apr 2029 expected diffuse large B-cell lymphoma of the central nervous system, large B-cell lymphoma Allison Winter Not yet recruiting No outcome recorded
Phase 1 NCT07381829 Background Oct 2025 → Dec 2026 expected — HC Biopharma Inc. Recruiting No outcome recorded
Phase 1 NCT07004244 Background Jun 2025 → Dec 2027 expected cancer Sichuan University Recruiting No outcome recorded
Phase 1 NCT06969612 Background May 2025 → May 2027 expected non-small cell lung carcinoma Peking University Cancer Hospital & Institute Recruiting No outcome recorded
Show all 635 trials opens the full record — a long page

Press releases naming this drug 77 releases

DateIssuerRelease
2024-09-18 Merck Sharp & Dohme LLC FDA Approves Merck’s KEYTRUDA® (pembrolizumab) Plus Pemetrexed and Platinum Chemotherapy as First-Line Treatment for Adult Patients With Unresectable Advanced or Metastatic Malignant Pleural Mesothelioma (MPM) merck.com ↗
2022-12-13 Lotus Pharmaceutical Lotus acquires Alimta® (Pemetrexed) in Taiwan from Lilly lotuspharm.com ↗
2022-10-27 Boryung Pharmaceutical Co., Ltd 보령, 비소세포폐암치료제 ‘알림타(ALIMTA)’ 인수 boryung.co.kr ↗
2022-05-26 Zydus Lifesciences Limited Zydus receives final approval to market Pemetrexed for Injection 2 zyduslife.com ↗
2022-03-24 Eli Lilly and Company Lilly Announces Complete Response Letter for Sintilimab in Combination with Pemetrexed and Platinum Chemotherapy for the First-Line Treatment of People with Nonsquamous Non-Small Cell Lung Cancer lilly.com ↗
2021-06-25 Zydus Lifesciences Limited Zydus Cadila receives tentative approval from USFDA for Pemetrexed for Injection zyduslife.com ↗
2021-06-25 Sandoz Sandoz announces EU launch of ready-to-dilute generic Pemetrexed to treat most prevalent form of lung cancer sandoz.com ↗
2021-06-25 Novartis Pharmaceuticals Sandoz announces EU launch of ready-to-dilute generic Pemetrexed to treat most prevalent form of lung cancer novartis.com ↗
2021-05-18 Innovent Biologics (Suzhou) Co. Ltd. U.S. FDA Accepts Regulatory Submission for Sintilimab in Combination with Pemetrexed and Platinum Chemotherapy for the First-Line Treatment of People with Nonsquamous Non-Small Cell Lung Cancer innoventbio.com ↗
2021-02-03 Innovent Biologics (Suzhou) Co. Ltd. Innovent and Lilly Jointly Announce the Approval of TYVYT® (sintilimab injection) by China NMPA in Combination with Pemetrexed and Platinum Chemotherapy as First-Line Therapy for Nonsquamous Non-Small Cell Lung Cancer innoventbio.com ↗
2020-09-21 Innovent Biologics (Suzhou) Co. Ltd. Innovent and Lilly Release Biomarker Results of TYVYT® (Sintilimab Injection) in Combination with ALIMTA® (Pemetrexed) and Platinum Chemotherapy as First-Line Treatment for Nonsquamous Non-Small Cell Lung Cancer at ESMO Virtual Congress 2020 innoventbio.com ↗
2020-08-08 Innovent Biologics (Suzhou) Co. Ltd. Innovent and Lilly Release Clinical Trial Results of Sintilimab in Combination with ALIMTA® (Pemetrexed) and Platinum Chemotherapy as First-Line Treatment for Nonsquamous NSCLC in an Oral Presentation at IASLC WCLC 2020 Virtual Presidential Symposium innoventbio.com ↗

Evidence & citations 40 cited values

Every value below carries the sentence it was read from. 1,332 sources stand behind the page.

FieldValueCited text
Known as Pemetrexed “Pemetrexed (500mg/m2) plus Carboplatin (AUC5)or Pemetrexed (500mg/m2) plus Cisplatin (75mg/m2) on Day 1 of 21day cycles (every 3 weeks) for 4\~6 cycles, followed by pemetrexed...” NCT04951648 ↗
1281

“Squamous cell carcinoma: Paclitaxel (175mg/m²) or Docetaxel (60-75 mg/m²) or Nab-paclitaxel (260mg/m²) plus Carboplatin (AUC=5)/Cisplatin (75 mg/m²) (to be determined by...” NCT07608159 ↗

“BACKGROUND: The efficacy and safety of axitinib, a potent and selective second-generation inhibitor of vascular endothelial growth factor receptors 1, 2, and 3 in combination...” PMID 24766732 ↗ Apr 2014

“An Open-label, Randomized Study to Evaluate the Effect of Tarceva, Compared With Alimta (Pemetrexed) or Taxotere (Docetaxel),on Survival in Patients With Advanced, Recurrent or...” NCT00556322 ↗

“intrathecal pemetrexed (administered via lumbar puncture, Ommaya reservoir, or intrathecal pump, with induction phase: 10mg twice weekly for 4 weeks, maintenance phase: 10mg...” NCT07398599 ↗

“Acceptable histology-specific PDC regimens include carboplatin plus paclitaxel or nab-paclitaxel (any histology), carboplatin/cisplatin plus pemetrexed (nonsquamous),...” NCT06865339 ↗

“platinum-based doublet chemotherapy (carboplatin [area under the curve ≤700 mg] plus pemetrexed [500 mg/m2 intravenous infusion every 3 weeks] or carboplatin [on day 1; area...” PMID 39486424 ↗ Oct 2024

“Tivantinib 360 mg twice daily in combination with other anti-cancer therapy (eg, erlotinib,sorafenib, pemetrexed, docataxel, gemcitabine, irinotecan, and/or cetuximab) at the...” NCT01178411 ↗

“IAM1363 monotherapy OR IAM1363 in combination with capecitabine + trastuzumab OR IAM1363 in combination with capecitabine + zanidatamab OR IAM1363 in combination with T-Dxd OR...” NCT06253871 ↗

“The intervention consists of furmonertinib (240 mg/d, po) combined with bevacizumab (15 mg/kg, every 3 weeks, ivgtt) and pemetrexed (50 mg) intrathecal chemotherapy /...” NCT06643000 ↗

“Non-small cell lung cancer (non-squamous cell carcinoma): pemetrexed plus carboplatin/cisplatin on Day 1 of each 21-day cycle for 4-6 cycles,pemetrexed every three weeks (Q3W)...” NCT06231680 ↗

Show 1,271 more sources

Known as Alimta “Pemetrexed (Alimta, Eli Lilly and Company) was administrated by intrathecal injection, first as induction therapy, twice per week for 2 weeks, followed by consolidation...” NCT06809530 ↗
54

“A Randomized Cost-minimization Trial Comparing Pemetrexed (Alimta®) Versus Docetaxel (Taxotere®) as Second Line Treatment in Advanced Non Small Cell Lung Cancer (NSCLC): Study...” NCT00284778 ↗

“Cisplatinum and pemetrexed (ALIMTA®) has become an effective first-line regimen for advanced and inoperable non-squamous NSCLC without somatic activating mutations of epidermal...” NCT01742767 ↗

“Pemetrexed (Alimta) is approved for use in patients with certain types of lung cancer called non-squamous non-small cell lung cancer (NSCLC) and malignant pleural mesothelioma.” NCT06794645 ↗

“Evaluation of pemetrexed (Alimta, LY231514) as second line chemotherapy in persistent or recurrent carcinoma of the cervix: a phase II study of the Gynecologic Oncology Group.” PMID 18455781 ↗ May 2008

“A Phase I-IIa Dose-Ranging Study of Pemetrexed (Alimta) Plus Cetuximab (Erbitux) in Patients With Recurrent Non-Small Cell Lung Cancer (NSCLC): Hoosier Oncology Group LUN04-79” NCT00216203 ↗

“Pemetrexed (Alimta, Eli Lilly and Company) is administrated by intrathecal injection, plus dexamethasone, twice per week for 2 weeks, followed by once per week for 4 weeks.” NCT05289908 ↗

“The regimen of pemetrexed (Alimta, Eli Lilly and Company) is 10/15/20 mg, plus dexamethasone 5 mg, twice per week for 2 weeks, followed by once per week for 2-4 weeks.” NCT03101579 ↗

“Pemetrexed (Alimta, LY231514) (NSC #698037) in Combination With Cisplatin (NSC #119875) in the Treatment of Advanced, Persistent, or Recurrent Carcinoma of the Cervix” NCT00691301 ↗

“Pemetrexed (also known as Alimta) has been approved by the FDA for the treatment of some lung cancers and has been shown to be effective in laboratory studies.” NCT00916630 ↗

“Phase I/II Trial of Abraxane® (ABI-007) and Alimta® (Pemetrexed) in Advanced Solid Tumors With Emphasis on Non-Small Cell Lung Cancer (NSCLC) and Breast Cancer” NCT00470548 ↗

Show 44 more sources

Known as Alimta (brand name for Pemetrexed) “Alimta (brand name for Pemetrexed)” NCT04107103 ↗
Known as Alimta (pemetrexed) “Alimta (pemetrexed)” NCT00516100 ↗
Known as Alimta [Registered Trademark] “A Phase II Trial of Pemetrexed (Alimta [Registered Trademark]) Combined With Sirolimus (Rapamycin, Rapamune [Registered Trademark]) in Subjects With Relapsed or Refractory NSCLC” NCT00923273 ↗
Known as Alimta: brand name of pemetrexed “Alimta: brand name of pemetrexed” NCT01593293 ↗
Known as Armisarte ChEMBL registry synonym — accepted as the source's own label CHEMBL225072 ↗
Known as Armisarte (previously pemetrexed actavis) ChEMBL registry synonym — accepted as the source's own label CHEMBL225072 ↗
Known as Ciambra ChEMBL registry synonym — accepted as the source's own label CHEMBL225072 ↗
Known as LY-231514 DISODIUM SALT ChEMBL registry synonym — accepted as the source's own label CHEMBL225072 ↗
Known as LY231514 “Evaluation of pemetrexed (Alimta, LY231514) as second line chemotherapy in persistent or recurrent carcinoma of the cervix: a phase II study of the Gynecologic Oncology Group.” PMID 18455781 ↗ May 2008
8

“Pemetrexed (Alimta, LY231514) (NSC #698037) in Combination With Cisplatin (NSC #119875) in the Treatment of Advanced, Persistent, or Recurrent Carcinoma of the Cervix” NCT00691301 ↗

“The purpose of this study is to evaluate the effects (good and bad) of LY231514 (ALIMTA) and Carboplatin on you and your non-small cell lung cancer.” NCT00051493 ↗

“ALIMTA (LY231514, Pemetrexed) Plus Oxaliplatin Administered Every 21 Days for First-Line Treatment of Patients With Advanced Colorectal Cancer.” NCT00034619 ↗

“A Phase 3 Trial of ALIMTA (LY231514, Pemetrexed) Plus GEMZAR Versus GEMZAR in Patients With Unresectable or Metastatic Cancer of the Pancreas.” NCT00035035 ↗

“A Phase II Trial of Pemetrexed (ALIMTA®, LY231514, IND #40061) as Salvage Therapy for Failed Low Risk Gestational Trophoblastic Tumor” NCT00096187 ↗

“A Phase I Study of Pemetrexed (LY231514, Alimta) in Children and Adolescents With Recurrent Solid Tumors” NCT00070473 ↗

“pemetrexed (Alimta, LY231514, IND #40061)” NCT00087100 ↗

“pemetrexed (ALIMTA LY231514, IND #40061)” NCT00087087 ↗

Known as NSC #698037 “Pemetrexed (Alimta, LY231514) (NSC #698037) in Combination With Cisplatin (NSC #119875) in the Treatment of Advanced, Persistent, or Recurrent Carcinoma of the Cervix” NCT00691301 ↗
Known as PEM “PURPOSE: To establish the maximum tolerated dose (MTD) and safety profile of bi-weekly Pemetrexed (PEM) when combined with weekly cisplatin (CDDP) and standard dose external...” PMID 26810581 ↗ Jan 2016
Known as Pemetrexed (Alimta) “Pemetrexed (Alimta™)” NCT00604461 ↗
5

“Pemetrexed (Alimta®)” NCT02983045 ↗

“Pemetrexed (Alimta)” NCT01588704 ↗

“Pemetrexed (Alimta)” NCT01746277 ↗

“pemetrexed (Alimta)” NCT01116219 ↗

“Pemetrexed/Alimta” NCT00517595 ↗

Known as Pemetrexed accord ChEMBL registry synonym — accepted as the source's own label CHEMBL225072 ↗
Known as Pemetrexed Alvogen “Drug: pemetrexed (Pemetrexed Alvogen) at 500 mg/m2 IV infusion on Day 1 of each 3 week cycle” NCT03562871 ↗
Known as Pemetrexed baxter ChEMBL registry synonym — accepted as the source's own label CHEMBL225072 ↗
Known as Pemetrexed diacid monohydrate ChEMBL registry synonym — accepted as the source's own label CHEMBL225072 ↗
Known as PEMETREXED DIPOTASSIUM ChEMBL registry synonym — accepted as the source's own label CHEMBL225072 ↗
Known as Pemetrexed Disodium “It is not yet known whether giving gemcitabine hydrochloride or pemetrexed disodium together with carboplatin is more effective with or without celecoxib in treating non-small...” NCT01041781 ↗
70

“Drugs used in chemotherapy, such as pemetrexed disodium and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping...” NCT00268437 ↗

“Drugs used in chemotherapy, such as pemetrexed disodium and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them...” NCT00334594 ↗

“Carboplatin plus Pemetrexed Disodium, administrated for 2-4 cycles, three weeks for one cycyles;Carboplatin 500mg/m2 d1,Pemetrexed Disodium AUV=5 d1,Q3W” NCT06208033 ↗

“Pemetrexed disodium for injection 500 mg per square meter, intravenous drip on day 1 in each treatment cycle.” NCT04482829 ↗

“Pemetrexed disodium in recurrent locally advanced or metastatic squamous cell carcinoma of the head and neck.” PMID 11531245 ↗ Sep 2001

“Patients receive pemetrexed disodium IV over 10 minutes and vinflunine IV over 20 minutes on day 1.” NCT00320073 ↗

“Patients receive cisplatin IV over 30 minutes and pemetrexed disodium IV over 10 minutes on day 1.” NCT00227539 ↗

“pemetrexed disodium IV is administered over 10 minutes 90 minutes following gemcitabine on day 8.” NCT00006007 ↗

“Patients receive pemetrexed disodium IV over 10 minutes and oxaliplatin IV over 2 hours on day 1.” NCT00470405 ↗

“Patients receive pemetrexed disodium IV over 10 minutes and cisplatin IV over 1-4 hours on day 1.” NCT00691301 ↗

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Known as Pemetrexed disodium f Injection “Pemetrexed disodium f Injection 500mg / m2, intravenous drip, on Day 1 in 21-day cycle.” NCT04439890 ↗
Known as Pemetrexed Disodium for Injection “Pemetrexed Disodium for Injection: Administration and Dosage: Intravenous infusion, 500mg/m\^2; Frequency and Duration of Administration: On the first day of each cycle,and 21...” NCT06514027 ↗
2

“CVL006(B006 Injection)、pemetrexed(Pemetrexed Disodium for Injection)、carboplatin(Carboplatin Injection)” NCT07157956 ↗

“For non-squamous NSCLC: Pemetrexed disodium for injection + Carboplatin” NCT04203485 ↗

Known as Pemetrexed fresenius kabi ChEMBL registry synonym — accepted as the source's own label CHEMBL225072 ↗
Known as Pemetrexed krka ChEMBL registry synonym — accepted as the source's own label CHEMBL225072 ↗
Known as Pemetrexed lilly ChEMBL registry synonym — accepted as the source's own label CHEMBL225072 ↗