Doxorubicin With or Without Sildenafil, With Analysis of Cardiac Markers

Summary

Sildenafil increases the therapeutic effect of doxorubicin used as treatment for cancers of solid tumors through both an increase in anti-tumor effects and protection from cardiac toxicity.

Timeline

Start

2011-08-11

Primary completion

2017-08-04

Completion

2018-01-19

Publications

• Results Poklepovic A, Qu Y, Dickinson M, Kontos MC, Kmieciak M, Schultz E, Bandopadhyay D, Deng X, Kukreja RC. Randomized study of doxorubicin-based chemotherapy regimens, with and without sildenafil, with analysis of intermediate cardiac markers. Cardiooncology. 2018;4:7. doi: 10.1186/s40959-018-0033-2. Epub 2018 Aug 29.

Drugs

Indications