Pilot Study on the Effect of Dexmedetomidine on Inflammatory Responses in Patients Undergoing Lumbar Spinal Fusion

Terminated 66 enrolled NYU Langone Health Hospira, now a wholly owned subsidiary of Pfizer · collab

RandomizedParallel-groupOpen-labelOther

Summary

The aim of the proposed study is to examine the effect of DEX on the inflammatory response in major surgery. More importantly, the investigators will correlate changes in the concentration of inflammatory mediators with meaningful clinical outcomes.

Timeline

Start: 2010-09
Primary completion: 2012-01
Completion: 2012-01

Outcome

Met primary endpoint

paper By POD 3, scores were significantly lower (-13.74 point difference, P=0.005) in the PFS group (169.3±3.87) than in the PFD group (183.04±2.76). PMID 22824921 ↗

paper DEX infusion during multilevel spinal fusions moderately improved the quality of recovery PMID 22824921 ↗

Publications

Results Bekker A, Haile M, Kline R, Didehvar S, Babu R, Martiniuk F, Urban M. The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. J Neurosurg Anesthesiol. 2013 Jan;25(1):16-24. doi: 10.1097/ANA.0b013e31826318af.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Dexmedetomidine	Other / unclassified	—	—