drugset / Trial / NCT01378741

Reducing Delirium After Cardiac Surgery: A Multifaceted Approach Of Perioperative Care

NCT01378741 ↗

RandomizedSingle-groupSingle-blindPrevention

Summary

The objective of this study is to reduce the incidence of postoperative delirium after cardiac surgery in the elderly patient. This proposal is a clinical trial designed to reduce delirium in patients undergoing cardiac surgery by replacing standard postoperative sedation protocols (propofol, midazolam, opioids) with a new alpha2-adrenergic receptor agonist (dexmedetomidine) possessing sedative, analgesic, and antinociceptive properties. Resource utilization analysis will be performed to determine cost effectiveness of the new treatment modality.

Timeline

Start
2011-04
Primary completion
2014-07
Completion
2015-04

Drugs

EvaluationDrugModalityDoseRoute
Comparator Dexmedetomidine Other / unclassified 0.2 ug/kg —
Comparator Dexmedetomidine Other / unclassified 0.7 ug/kg —
Comparator Propofol Small molecule 2 mg/kg —
Comparator Propofol Small molecule 6 mg/kg —

Indications