Effect of Glucose-insulin-potassium Solution on Myocardial Protection During Off-pump Coronary Bypass Surgery in Patients With Acute Coronary Syndrome

Phase 4 Completed 66 enrolled Yonsei University

RandomizedParallel-groupQuadruple-blindPrevention

Summary

Patients undergoing multivessel off-pump coronary bypass surgery (OPCAB) inevitably experience cumulative ischemia-reperfusion injury at myocardium. Glucose-insulin-potassium (GIK) is a potentially useful adjunct to myocardial protection. This study was designed to evaluate the effects of GIK infusion on myocardium in patients undergoing OPCAB. Patients undergoing OPCAB with acute coronary syndrome are randomly assigned to GIK or Control group. The trial is double-blind and conducted at a single center.

Timeline

Start: 2011-02
Primary completion: 2012-02
Completion: 2012-02

Outcome

Met primary endpoint

paper troponin-T [0.20 (0.13-0.49) vs 0.48 (0.18-0.91) ng ml(-1), P<0.0001] values after reperfusion were significantly lower in the GIK group compared with the control group. PMID 22986417 ↗

Publications

Shim JK, Yang SY, Yoo YC, Yoo KJ, Kwak YL. Myocardial protection by glucose-insulin-potassium in acute coronary syndrome patients undergoing urgent multivessel off-pump coronary artery bypass surgery. Br J Anaesth. 2013 Jan;110(1):47-53. doi: 10.1093/bja/aes324. Epub 2012 Sep 17.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Glucose	Unknown	50 %	—
Subject	Potassium	Small molecule	80 meq	—
Subject	regular insulin	Protein / enzyme biologic	325 iu	—