drugset / Trial / NCT01396200
Cyclophosphamide and Pulse Dexamethasone With Rapamycin or Hydroxychloroquine
Non-randomizedParallel-groupTreatment
Summary
The purpose of this study is to determine the feasibility of giving (i) rapamycin or (ii) hydroxychloroquine (HCQ), with standard doses of infusional cyclophosphamide and pulse dexamethasone (cy/dex) for patients with relapsed/refractory multiple myeloma, as well as the feasibility of obtaining multiple blood and bone marrow samples during treatment to assess the pharmacodynamic effects of the treatment.
Timeline
- Start
- 2011-06
- Primary completion
- 2012-10
- Completion
- 2012-10
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Hydroxychloroquine | Small molecule | 600 mg | Oral |
| Subject | Hydroxychloroquine | Small molecule | 800 mg | Oral |
| Subject | Sirolimus | Small molecule | 3 mg | Oral |
| Subject | Sirolimus | Small molecule | 4 mg | Oral |