The Inhibitory Effect of Metformin on Gluconeogenesis in Relation to Polymorphisms in Organic Cation Transporter 1

Summary

The aim of the study is to evaluate the pharmacodynamic impact of metformin in healthy Caucasian volunteers with and without single polymorphisms M420del or R61C in OCT1, thus the study hypothesis is that metformin only affect the hepatic gluconeogenesis in healthy volunteers with functional OCT1-transporters.

Timeline

Start

2012-01

Primary completion

2012-12

Completion

2012-12

Publications

• Kolnes KJ, Moller PM, Kruse R, Christensen MMH, Kjobsted R, Hey-Mogensen M, Andersen B, Handberg A, Hojlund K. Metformin increases glycolysis and the stress-induced cytokine GDF15 but not FGF21 in humans. Front Endocrinol (Lausanne). 2026 Mar 18;17:1797525. doi: 10.3389/fendo.2026.1797525. eCollection 2026.
• Christensen MM, Hojlund K, Hother-Nielsen O, Stage TB, Damkier P, Beck-Nielsen H, Brosen K. Endogenous glucose production increases in response to metformin treatment in the glycogen-depleted state in humans: a randomised trial. Diabetologia. 2015 Nov;58(11):2494-502. doi: 10.1007/s00125-015-3733-2. Epub 2015 Aug 14.

Drugs

Indications