drugset / Trial / NCT01401192

Pemetrexed/Cisplatin Versus Gemcitabine/Cisplatin According to Thymidylate Synthase Expression

NCT01401192 ↗

Phase 2 Unknown 304 enrolled Samsung Medical Center
RandomizedParallel-groupOpen-labelTreatment

Summary

This study trys to evaluate the predictive role of thymidylate synthase expression for pemetrexed/cisplatin in Non-small Cell Lung Cancer (NSCLC).

Timeline

Start
2011-07
Primary completion
2013-12
Completion
—

Outcome

Met primary endpoint

paper interaction P = .0084 PMID 26124486 ↗

Drugs

EvaluationDrugModalityDoseRoute
Comparator Cisplatin Other / unclassified 70 mg/m2 —
Subject Gemcitabine Small molecule 1000 mg/m2 —
Comparator Pemetrexed Small molecule 500 mg/m2 —