drugset / Trial / NCT01402375
Comparing the Efficacy of Oral Opioids for Outpatient Acute Pain Management After ED Discharge Discharge
RandomizedParallel-groupDouble-blindSupportive care
Summary
There will be 3 randomized, double-blinded clinical trials to help determine which of commonly prescribed oral opioid combination is most effective in managing acute extremity pain after discharge from the adult emergency department. The first trial compares hydrocodone 5mg / acetaminophen 500mg to codeine 30mg/acetaminophen 300mg. The second trial compares oxycodone 5mg/acetaminophen 325mg to codeine 30mg/acetaminophen 300mg. The third trial compares oxycodone 5mg/acetaminophen 325 mg to hydrocodone 5mg/acetaminophen 325 mg.
Timeline
- Start
- 2012-01
- Primary completion
- 2014-11
- Completion
- 2014-11
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Acetaminophen | Small molecule | 300 mg | Oral |
| Subject | Acetaminophen | Small molecule | 325 mg | Oral |
| Subject | Acetaminophen | Small molecule | 500 mg | Oral |
| Comparator | Codeine | Small molecule | 30 mg | Oral |
| Subject | Hydrocodone | Unknown | 5 mg | Oral |
| Subject | Oxycodone | Other / unclassified | 5 mg | Oral |
Indications
No indication recorded.